{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:43:07Z","timestamp":1792068187986,"version":"4.4.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011958","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["6110-00173B"],"award-info":[{"award-number":["6110-00173B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997\u20132016 (n\u2005=\u20051745) and a comparison cohort from the general population individually matched on date of birth and sex (n\u2005=\u200517\u2005450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mortality in the first year was higher among patients with ECI (mortality rate ratio\u2005[MRR] =\u200510.0; 95% confidence interval [CI], 4.17\u201324.1), but thereafter mortality was not higher (MMR\u2005=\u20050.94; 95% CI, 0.47\u20131.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Diagnosis of an ECI had no substantial impact on long-term survival, health, or social\/educational functioning.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa151","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T19:10:38Z","timestamp":1585681838000},"page":"619-627","source":"Crossref","is-referenced-by-count":11,"title":["Long-Term Survival, Health, Social Functioning, and Education in Patients With an Enterovirus Central Nervous System Infection, Denmark, 1997\u20132016"],"prefix":"10.1093","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-8948","authenticated-orcid":false,"given":"Lars H","family":"Omland","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Holm-Hansen","sequence":"additional","affiliation":[{"name":"Department of Virus and Specialist Microbiological Diagnostics, Statens Serum Institute, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mette","family":"Lebech","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram B","family":"Dessau","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-814X","authenticated-orcid":false,"given":"Jacob","family":"Bodilsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna S","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Roed","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus B","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend","family":"Ellermann-Eriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Midgley","sequence":"additional","affiliation":[{"name":"Department of Virus and Specialist Microbiological Diagnostics, Statens Serum Institute, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Benfield","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Brit E","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian \u00d8","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"Rothman","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Epidemiology, Boston University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik T","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Epidemiology, Boston University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea K","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Virus and Specialist Microbiological Diagnostics, Statens Serum Institute, Copenhagen, Denmark"},{"name":"Department of Infectious Diseases, University of Southern Denmark, Odense, Denmark"},{"name":"Centre for Global Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Obel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"2020072311065917200_CIT0001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jcv.2018.01.008","article-title":"Recommendations for enterovirus diagnostics and characterisation within and beyond Europe","volume":"101","author":"Harvala","year":"2018","journal-title":"J Clin Virol"},{"key":"2020072311065917200_CIT0002","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S1473-3099(18)30245-7","article-title":"Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort 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