{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:55:52Z","timestamp":1790265352493,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherche sur le SIDA et les H\u00e9patites Virales","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Kaposi sarcoma (KS)\u2013associated herpesvirus (KSHV) subtype depends mostly on patient origin. The current study aimed to assess KSHV diversity in a population of men who have sex with men (MSM) living in France.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study included 264 patients. In 65 MSM, including 57 human immunodeficiency virus (HIV)\u2013infected men with KS, multicentric Castleman disease, or primary effusion lymphoma and 8 HIV-uninfected men receiving HIV preexposure prophylaxis (PrEP), we performed KSHV typing with K1 open reading frame Sanger and KSHV whole-genome sequencing. In 199 other patients, we performed real-time polymerase chain reaction screening for the new variant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that 51% of KSHV-strains were subtype C (85% C3), and 33% were subtype A. Four patients with severe KSHV disease (2 with visceral KS, 1 with multicentric Castleman disease, and 1 with primary effusion lymphoma) and 1 asymptomatic PrEP user had a new variant resembling the Ugandan subtype F, but with different K1 open reading frame and KSHV whole-genome sequences and a different epidemiological context (MSM vs African population). Its prevalence was 4.5% in Caucasian MSM, and it was absent in other epidemiological groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Subtype C predominated among MSM living in France. The new F variant was identified in Caucasian MSM and associated with severe KSHV disease, suggesting that subtype F could be split into F1 and F2 variants. Careful screening for this variant may be required in MSM, given the severe clinical presentation of associated diseases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa180","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T19:12:12Z","timestamp":1586459532000},"page":"1320-1328","source":"Crossref","is-referenced-by-count":32,"title":["New Kaposi\u2019s sarcoma-associated herpesvirus variant in men who have sex with men associated with severe pathologies"],"prefix":"10.1093","volume":"222","author":[{"given":"Aude","family":"Jary","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Piti\u00e9-Salp\u00eatri\u00e8re - Charles Foix, Laboratoire de Virologie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Leducq","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Piti\u00e9-Salp\u00eatri\u00e8re - Charles Foix, Laboratoire de Virologie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Desire","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Piti\u00e9-Salp\u00eatri\u00e8re - Charles Foix, Laboratoire de Virologie, Paris, 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