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During the course of infection it can be found in microaerobic environments, which influences virulence factor expression. From a previous transcriptomic analysis of A. baumannii ATCC 17978 under microaerobiosis, we know the gene pstS is overexpressed under microaerobiosis. Here, we studied its role in A. baumannii virulence. pstS loss significantly decreased bacterial adherence and invasion into A549 cells and increased A549 cell viability. pstS loss also reduced motility and biofilm-forming ability of A. baumannii. In a peritoneal sepsis murine model, the minimum lethal dose required by A. baumannii ATCC 17978 \u0394pstS was lower compared to the wild type (4.3 vs 3.2 log colony forming units\/mL, respectively), and the bacterial burden in tissues and fluids was lower. Thus, the loss of the phosphate sensor PstS produced a decrease in A. baumannii pathogenesis, supporting its role as a virulence factor.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa201","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T19:09:57Z","timestamp":1587409797000},"page":"1204-1212","source":"Crossref","is-referenced-by-count":16,"title":["Role of PstS in the Pathogenesis of Acinetobacter baumannii Under Microaerobiosis and Normoxia"],"prefix":"10.1093","volume":"222","author":[{"given":"Mar\u00eda Luisa","family":"Gil-Marqu\u00e9s","sequence":"first","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Institute of Biomedicine of Seville, University Hospital Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cient\u00edficas, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Labrador Herrera","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Institute of Biomedicine of Seville, University Hospital Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cient\u00edficas, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mir\u00f3 Canturri","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Institute of Biomedicine of Seville, University Hospital Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cient\u00edficas, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f3nimo","family":"Pach\u00f3n","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Institute of Biomedicine of Seville, University Hospital Virgen 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