{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:53:20Z","timestamp":1791395600993,"version":"4.3.3"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"US Army Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense","award":["W911QY-16-9-0001"],"award-info":[{"award-number":["W911QY-16-9-0001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Marburg virus (MARV) is a filovirus with documented human case-fatality rates of up to 90%. Here, we evaluated the therapeutic efficacy of remdesivir (GS-5734) in nonhuman primates experimentally infected with MARV. Beginning 4 or 5 days post inoculation, cynomolgus macaques were treated once daily for 12 days with vehicle, 5 mg\/kg remdesivir, or a 10-mg\/kg loading dose followed by 5 mg\/kg remdesivir. All vehicle-control animals died, whereas 83% of animals receiving a 10-mg\/kg loading dose of remdesivir survived, as did 50% of animals receiving a 5-mg\/kg remdesivir regimen. Remdesivir-treated animals exhibited improved clinical scores, lower plasma viral RNA, and improved markers of kidney function, liver function, and coagulopathy versus vehicle-control animals. The small molecule remdesivir showed therapeutic efficacy in this Marburg virus disease model with treatment initiation 5 days post inoculation, supporting further assessment of remdesivir for the treatment of Marburg virus disease in humans.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa290","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T15:10:13Z","timestamp":1590505813000},"page":"1894-1901","source":"Crossref","is-referenced-by-count":78,"title":["Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus"],"prefix":"10.1093","volume":"222","author":[{"given":"Danielle P","family":"Porter","sequence":"first","affiliation":[{"name":"Gilead Sciences Inc., Foster City, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M","family":"Weidner","sequence":"additional","affiliation":[{"name":"Geneva Foundation, Tacoma, Washington, USA"},{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gomba","sequence":"additional","affiliation":[{"name":"Geneva Foundation, Tacoma, Washington, USA"},{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Bannister","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., Foster City, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Blair","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., Foster City, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jordan","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., Foster City, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Wells","sequence":"additional","affiliation":[{"name":"Geneva Foundation, Tacoma, Washington, USA"},{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Geneva Foundation, Tacoma, Washington, USA"},{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Garza","sequence":"additional","affiliation":[{"name":"Geneva Foundation, Tacoma, Washington, USA"},{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Van 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