{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:09:18Z","timestamp":1790834958594,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005736","name":"Universit\u00e9 Paris Diderot","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-CE15-0017"],"award-info":[{"award-number":["ANR-15-CE15-0017"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-INSB-04-01"],"award-info":[{"award-number":["ANR-10-INSB-04-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["RYC-2018-024985-I"],"award-info":[{"award-number":["RYC-2018-024985-I"]}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The bacterial pathogen Listeria monocytogenes invades host cells, ruptures the internalization vacuole, and reaches the cytosol for replication. A high-content small interfering RNA (siRNA) microscopy screen allowed us to identify epithelial cell factors involved in L. monocytogenes vacuolar rupture, including the serine\/threonine kinase Taok2. Kinase activity inhibition using a specific drug validated a role for Taok2 in favoring L. monocytogenes cytoplasmic access. Furthermore, we showed that Taok2 recruitment to L. monocytogenes vacuoles requires the presence of pore-forming toxin listeriolysin O. Overall, our study identified the first set of host factors modulating L. monocytogenes vacuolar rupture and cytoplasmic access in epithelial cells.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa367","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T19:11:19Z","timestamp":1592593879000},"page":"1005-1010","source":"Crossref","is-referenced-by-count":14,"title":["A Role for Taok2 in <i>Listeria monocytogenes<\/i> Vacuolar Escape"],"prefix":"10.1093","volume":"225","author":[{"given":"Juan J","family":"Quereda","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur, Paris, France"},{"name":"Departamento Producci\u00f3n y Sanidad Animal, Salud P\u00fablica Veterinaria y Ciencia y Tecnolog\u00eda de los Alimentos. Facultad de Veterinaria. Universidad Cardenal Herrera-CEU, CEU Universities. Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Morel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Lopez-Montero","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Dynamique des Interactions H\u00f4te-Pathog\u00e8ne, Institut Pasteur, Paris, France"},{"name":"Institut Pasteur, CNRS UMR3691, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Ziveri","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Rolland","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des 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