{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:49:06Z","timestamp":1782877746586,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Genome BC COVID-19 Rapid Response","award":["COV-115"],"award-info":[{"award-number":["COV-115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>False-negative severe acute respiratory syndrome coronavirus 2 test results can negatively impact the clinical and public health response to coronavirus disease 2019 (COVID-19). We used droplet digital polymerase chain reaction (ddPCR) to demonstrate that human DNA levels, a stable molecular marker of sampling quality, were significantly lower in samples from 40 confirmed or suspected COVID-19 cases that yielded negative diagnostic test results (ie, suspected false-negative test results) compared with a representative pool of 87 specimens submitted for COVID-19 testing. Our results support suboptimal biological sampling as a contributor to false-negative COVID-19 test results and underscore the importance of proper training and technique in the collection of nasopharyngeal specimens.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa370","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T23:16:02Z","timestamp":1592608562000},"page":"899-902","source":"Crossref","is-referenced-by-count":81,"title":["Suboptimal Biological Sampling as a Probable Cause of False-Negative COVID-19 Diagnostic Test Results"],"prefix":"10.1093","volume":"222","author":[{"given":"Natalie N","family":"Kinloch","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada"},{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Division of Medical Microbiology and Virology, St. Paul\u2019s Hospital, Vancouver, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanson J","family":"Brumme","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, Canada"},{"name":"Department of Medicine, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Dong","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Dong","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS, Vancouver, 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