{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:56:18Z","timestamp":1790841378738,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Wesfarmers"},{"name":"Coordination for the Improvement of Higher Education Personnel, Ministry of Education, Brazil","award":["440893\/2016-0"],"award-info":[{"award-number":["440893\/2016-0"]}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["88881.130729\/2016-01"],"award-info":[{"award-number":["88881.130729\/2016-01"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa383","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T11:12:56Z","timestamp":1593083576000},"page":"435-440","source":"Crossref","is-referenced-by-count":38,"title":["Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly"],"prefix":"10.1093","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-4136","authenticated-orcid":false,"given":"Denise","family":"Anderson","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, University of Western Australia, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o I C F","family":"Neri","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of Rio Grande do Norte, Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssio R M","family":"Souza","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of Rio Grande do Norte, Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna G","family":"Valverde","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of Rio Grande do Norte, Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9lio M G","family":"De Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of Rio Grande do Norte, Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D S B","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Maranh\u00e3o, S\u00e3o Luis, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca C C","family":"Branco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Maranh\u00e3o, S\u00e3o Luis, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivia M R","family":"Arrais","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Federal University of Rio Grande do Norte, Empresa Brasileira de Servicos Hospitalares, Natal, Rio de Grande do Norte, 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