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Chan School of Public Health","doi-asserted-by":"publisher","award":["HD052102"],"award-info":[{"award-number":["HD052102"]}],"id":[{"id":"10.13039\/100008548","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tulane University School of Medicine","award":["HD052104"],"award-info":[{"award-number":["HD052104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Understanding in utero transfer of antiretrovirals is critical for interpreting safety. Hair levels measure cumulative exposure. We measured tenofovir (TFV) concentrations in hair at delivery among women living with human immunodeficiency virus receiving TFV disoproxil fumarate-based treatment and their infants, using liquid chromatography\u2013tandem mass spectrometry. Among 103 mother-infant pairs, the mean log10 ratio of infant-to-maternal TFV levels was 1.08 (95% confidence interval, .97\u20131.20). TFV transfer was 60% lower from mothers who had preterm compared with term deliveries and 42% lower from mothers who had cesarean compared with vaginal deliveries. Like prior studies assessing transfer via short-term measures (plasma, cord blood, amniotic fluid), we found high cumulative transfer using hair.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa398","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:35:25Z","timestamp":1593218125000},"page":"638-644","source":"Crossref","is-referenced-by-count":2,"title":["Extent of In Utero Transfer of Tenofovir From Mother to Fetus: A Paired Analysis of Hair Specimens Collected at Birth From a Cohort in the United States"],"prefix":"10.1093","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-7191","authenticated-orcid":false,"given":"Jillian","family":"Pintye","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Huo","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. 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