{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:38:46Z","timestamp":1790519926382,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100016034","name":"Fondation du Rein","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Nationale Contre le Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cytomegalovirus (CMV) is a major infectious cause of death and disease after transplantation. We have previously demonstrated that the tissue-associated adaptive V\u03b42neg \u03b3\u03b4 T cells are key effectors responding to CMV and associated with recovery, contrasting with their innatelike circulating counterparts, the V\u03b39posV\u03b42pos T cells that respond to phosphoantigens but not to CMV. A third V\u03b39negV\u03b42pos subgroup with adaptive functions has been described in adults. In the current study, we demonstrate that these V\u03b39negV\u03b42pos T cells are also components of the CMV immune response while presenting with distinct characteristics from V\u03b42neg \u03b3\u03b4 T cells. In a cohort of kidney transplant recipients, CMV seropositivity was the unique clinical parameter associated with V\u03b39negV\u03b42pos T-cell expansion and differentiation. Extensive phenotyping demonstrated their substantial cytotoxic potential and activation during acute CMV primary infection or reinfection. In vitro, V\u03b39negV\u03b42pos T cells responded specifically to CMV-infected cells in a T-cell receptor\u2013dependent manner and through strong interferon \u03b3 production. Finally, V\u03b39negV\u03b42pos T cells were the only \u03b3\u03b4 T-cell subset in which expansion was tightly correlated with the severity of CMV disease. To conclude, our results identify a new player in the immune response against CMV and open interesting clinical perspectives for using V\u03b39negV\u03b42pos T cells as an immune marker for CMV disease severity in immunocompromised patients.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa400","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T11:06:59Z","timestamp":1593688019000},"page":"655-666","source":"Crossref","is-referenced-by-count":34,"title":["Characterization of a Unique \u03b3\u03b4 T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity"],"prefix":"10.1093","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-3825","authenticated-orcid":false,"given":"Hannah","family":"Kaminski","sequence":"first","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis, Bordeaux University Hospital, Bordeaux, France"},{"name":"Univ. 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