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Due to the disease severity, TBEV requires handling under heightened biosafety measures. The establishment and validation of inactivation procedures is a prerequisite for downstream analyses and management of occupational exposure. Therefore, different procedures for TBEV inactivation were tested. Our results suggest that TBEV is susceptible to inactivation by heat, acidic pH, different concentrations of alcohol, formaldehyde, or detergents, and exposure to UV irradiation, which may depend on sample size and composition.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa405","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T19:11:59Z","timestamp":1593717119000},"page":"714-718","source":"Crossref","is-referenced-by-count":9,"title":["Susceptibility of Tick-Borne Encephalitis Virus to Inactivation by Heat, Acidic pH, Chemical, or UV Treatment"],"prefix":"10.1093","volume":"223","author":[{"given":"Laura","family":"Wiesner","sequence":"first","affiliation":[{"name":"Institute for Physiological Chemistry, University of Veterinary Medicine, Hannover, Germany"},{"name":"Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, 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