{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:00:43Z","timestamp":1790413243606,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5-U01-AI122275"],"award-info":[{"award-number":["5-U01-AI122275"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5-R01-AI132140"],"award-info":[{"award-number":["5-R01-AI132140"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Murine infections with most Coccidioides spp. strains are lethal by 3 weeks, limiting the study of immune responses. Coccidioides posadasii, strain 1038 (Cp1038), while slowly lethal, resulted in protracted survival of C57BL\/6 (B6) mice. In resistant (B6D2)F1\/J mice, lung fungal burdens stabilized by week 4 without progression through week 16, better modeling human coccidioidal infections after their immunologic control. Immunodeficient tumor necrosis factor (Tnf) \u03b1 knockout (KO) and interferon (Ifn) \u03b3 receptor 1 (Ifn-\u03b3r1) KO mice survived a median of 22.5 and 34 days, compared with 70 days in B6 mice (P = .001 and P &amp;lt; .01, respectively), though 14-day lung fungal burden studies showed little difference between Ifn-\u03b3r1 KO and B6 mice. B6 mice showed peak concentrations of key inflammatory lung cytokines, including interleukin 6, 23, and 17A, Tnf-\u03b1, and Ifn-\u03b3, only after 4 weeks of infection. The slower progression in B6 and the acquired fungal burden stability in B6D2 mice after Cp1038 infection greatly increases the array of possible immunologic studies.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa419","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T19:10:00Z","timestamp":1594408200000},"page":"166-173","source":"Crossref","is-referenced-by-count":25,"title":["A Chronic Murine Disease Model of Coccidioidomycosis Using <i>Coccidioides posadasii<\/i>, Strain 1038"],"prefix":"10.1093","volume":"223","author":[{"given":"Lisa F","family":"Shubitz","sequence":"first","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Powell","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA"},{"name":"Department of Immunobiology, The University of 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