{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:06:29Z","timestamp":1793023589779,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP6 036894"],"award-info":[{"award-number":["FP6 036894"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7 259679"],"award-info":[{"award-number":["FP7 259679"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7 HEALTH-2007-2.4.5-10"],"award-info":[{"award-number":["FP7 HEALTH-2007-2.4.5-10"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7 HEALTH-F2-2009\u2013223004"],"award-info":[{"award-number":["FP7 HEALTH-F2-2009\u2013223004"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010070","name":"SenterNovem","doi-asserted-by":"publisher","award":["IGE01014"],"award-info":[{"award-number":["IGE01014"]}],"id":[{"id":"10.13039\/501100010070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010070","name":"SenterNovem","doi-asserted-by":"publisher","award":["IGE5007"],"award-info":[{"award-number":["IGE5007"]}],"id":[{"id":"10.13039\/501100010070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014725","name":"Centre for Medical Systems Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Genomics Initiative","award":["05040202"],"award-info":[{"award-number":["05040202"]}]},{"name":"Netherlands Genomics Initiative","award":["050-060-810"],"award-info":[{"award-number":["050-060-810"]}]},{"DOI":"10.13039\/501100003246","name":"Netherlands Organization for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health, Welfare and Sports"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01 AG08761"],"award-info":[{"award-number":["P01 AG08761"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8\u201311.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and\/or IgG antibody titer, in quartiles after adjusting for confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CMV-seropositivity was seen in 47%\u201379% of 10 122 white community-dwelling adults aged 59\u201393 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97\u20131.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83\u20131.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04\u20131.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99\u20131.29). The lack of increased mortality risk was confirmed in subanalyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa480","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T19:15:58Z","timestamp":1596741358000},"page":"238-246","source":"Crossref","is-referenced-by-count":50,"title":["Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults"],"prefix":"10.1093","volume":"223","author":[{"given":"Sijia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands"},{"name":"Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3600-0163","authenticated-orcid":false,"given":"Graham","family":"Pawelec","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Health Sciences North Research Institute, Sudbury, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Trompet","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldeck","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Fairfax Centre, Kidlington, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laust H","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Methods and Analysis, Statistics Denmark, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Eline","family":"Slagboom","sequence":"additional","affiliation":[{"name":"Section of Molecular Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-5292","authenticated-orcid":false,"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[{"name":"Danish Aging Research Center, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobijn","family":"Gussekloo","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands"},{"name":"Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Kearney","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan M","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-1823","authenticated-orcid":false,"given":"Ian","family":"Ford","sequence":"additional","affiliation":[{"name":"Robertson Center for Biostatistics, University of Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi G J","family":"Westendorp","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands"},{"name":"Leyden Academy on Vitality and Ageing, Leiden, the Netherlands"},{"name":"Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-1724","authenticated-orcid":false,"given":"Andrea B","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia"},{"name":"Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement 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