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However, the extent to which environmental changes from water resource development will impact malaria epidemiology remains unclear. This study was designed to compare the sensitivity of molecular markers used in deep amplicon sequencing for evaluating malaria transmission intensities and to assess malaria transmission intensity at various proximities to an irrigation scheme. Compared to ama1, csp, and msp1 amplicons, cpmp required the smallest sample size to detect differences in infection complexity between transmission risk zones. Transmission intensity was highest within 5 km of the irrigation scheme by polymerase chain reaction positivity rate, infection complexity, and linkage disequilibrium. The irrigated area provided a source of parasite infections for the surrounding 2- to 10-km area. This study highlights the suitability of the cpmp amplicon as a measure for transmission intensities and the impact of irrigation on microgeographic epidemiology of malaria parasites.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa520","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T03:36:51Z","timestamp":1597203411000},"page":"1456-1465","source":"Crossref","is-referenced-by-count":8,"title":["Microgeographic Epidemiology of Malaria Parasites in an Irrigated Area of Western Kenya by Deep Amplicon Sequencing"],"prefix":"10.1093","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2569-5059","authenticated-orcid":false,"given":"Elizabeth","family":"Hemming-Schroeder","sequence":"first","affiliation":[{"name":"Program in Public Health, University of California, Irvine, Irvine, California, USA"},{"name":"Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daibin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Program in Public Health, University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon","family":"Kibret","sequence":"additional","affiliation":[{"name":"Program in Public Health, University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Chie","sequence":"additional","affiliation":[{"name":"Program in Public Health, University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chieh","family":"Lee","sequence":"additional","affiliation":[{"name":"Program in Public Health, University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofa","family":"Zhou","sequence":"additional","affiliation":[{"name":"Program in Public Health, University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrysone","family":"Atieli","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Development, Maseno University, Kisumu, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Githeko","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W","family":"Kazura","sequence":"additional","affiliation":[{"name":"Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyun","family":"Yan","sequence":"additional","affiliation":[{"name":"Program in Public Health, University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"2021042315541147800_CIT0001","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s10393-015-1029-0","article-title":"The influence of dams on malaria transmission in sub-Saharan Africa","volume":"14","author":"Kibret","year":"2017","journal-title":"Ecohealth"},{"key":"2021042315541147800_CIT0002","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.actatropica.2003.09.014","article-title":"Malaria transmission in southern Madagascar: influence of the environment and hydro-agricultural works in sub-arid and humid regions. 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