{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:54:03Z","timestamp":1790830443549,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Health Care and Innovation of Guangzhou Project","award":["201704020213"],"award-info":[{"award-number":["201704020213"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidemiologic reports suggest that the most severe or fatal adenoviral disease in children might be associated with human adenovirus (HAdV) type 7. However, the pathogenesis of HAdV-7\u2013induced severe disease remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HAdV-3 and HAdV-7 replication kinetics and the host response to infection were compared using ex vivo human lung tissue cultures. Furthermore, cytokine and chemokine levels and the presence of adenovirus DNA in the serum of hospitalized children infected with HAdV-7 (n = 65) or HAdV-3 (n = 48) were measured (using a multiplex immunoassay and Taqman real-time polymerase chain reaction, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 471 HAdV-positive specimens, HAdV-3 or HAdV-7 was the most prevalent genotype during 2014\u20132016 or 2018, respectively. The incidence of severe pneumonia was higher in HAdV-7\u2013infected than in HAdV-3\u2013infected individuals (30.1% vs 4.5%, respectively). HAdV-7 replicated more efficiently than HAdV-3 ex vivo. Interferon-induced protein 10, interleukin 6, and monocyte chemoattractant protein 1 levels were significantly higher in HAdV-7\u2013infected than in HAdV-3\u2013infected children. Adenovirus DNA was detected in serum samples from 40% and 4.2% of HAdV-7\u2013 and HAdV-3\u2013infected children, respectively. Furthermore, viremia was strongly associated with severe clinical presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The pathogenesis of HAdV-7\u2013induced severe disease was probably associated with high replication competence and hyperinflammatory responses. The detection of adenovirus DNA in blood may be useful in assessing risk for severe disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa524","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T07:53:25Z","timestamp":1597391605000},"page":"1390-1399","source":"Crossref","is-referenced-by-count":37,"title":["Clinical Features, Replication Competence, and Innate Immune Responses of Human Adenovirus Type 7 Infection"],"prefix":"10.1093","volume":"223","author":[{"given":"Qigao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Central Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, 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