{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:36:49Z","timestamp":1780583809304,"version":"3.54.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Kenneth and Dianne Wright Center for Clinical and Translational Research","award":["UL1TR002649"],"award-info":[{"award-number":["UL1TR002649"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Fibrosis-4 Index (FIB-4), developed to predict fibrosis in liver disease, was used to identify patients with coronavirus disease 2019 who will require ventilator support as well as those associated with 30-day mortality. Multivariate analysis found obesity (odds ratio [OR], 4.5), diabetes mellitus (OR, 2.55), and FIB-4 \u22652.67 (OR, 3.09) independently associated with need for mechanical ventilation. When controlling for ventilator use, sex, and comorbid conditions, FIB-4 \u22652.67 was also associated with increased 30-day mortality (OR, 8.4 [95% confidence interval, 2.23\u201331.7]). Although it may not be measuring hepatic fibrosis, its components suggest that increases in FIB-4 may be reflecting systemic inflammation associated with poor outcomes.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa550","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T19:11:40Z","timestamp":1598382700000},"page":"1794-1797","source":"Crossref","is-referenced-by-count":37,"title":["The Fibrosis-4 Index Is Associated With Need for Mechanical Ventilation and 30-Day Mortality in Patients Admitted With Coronavirus Disease 2019"],"prefix":"10.1093","volume":"222","author":[{"given":"Richard K","family":"Sterling","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA"},{"name":"Division of Infectious Diseases, Virginia Commonwealth University, Richmond, Virginia, USA"},{"name":"C. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tavis","family":"Oakes","sequence":"additional","affiliation":[{"name":"C. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas S","family":"Gal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Stevens","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Virginia Commonwealth University, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"deWit","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine and Critical Care, Virginia Commonwealth University, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun J","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA"},{"name":"C. 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