{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:06:46Z","timestamp":1790057206034,"version":"4.0.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa566","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T03:36:38Z","timestamp":1599017798000},"page":"109-112","source":"Crossref","is-referenced-by-count":17,"title":["No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis"],"prefix":"10.1093","volume":"223","author":[{"given":"Robert M","family":"Verdijk","sequence":"first","affiliation":[{"name":"Department of Pathology, Section Ophthalmic Pathology, Erasmus Medical Center (MC) University Medical Center Rotterdam, Rotterdam, The Netherlands"},{"name":"Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J D","family":"Ouwendijk","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W A M","family":"Kuijpers","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Albert Schweitzer Hospital, Dordrecht, The Netherlands"},{"name":"Department of Ophthalmology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands"},{"name":"Department of Ophthalmology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges M G M","family":"Verjans","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"2021010414102206700_CIT0001","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1179\/174313208X319107","article-title":"Ischemic optic neuropathy","volume":"30","author":"Athappilly","year":"2008","journal-title":"Neurol Res"},{"key":"2021010414102206700_CIT0002","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/rheumatology\/kez385","article-title":"Sensitivity of temporal artery biopsy in the diagnosis of giant cell arteritis: a systematic literature review and meta-analysis","volume":"59","author":"Rubenstein","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"2021010414102206700_CIT0003","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/01658107.2019.1604763","article-title":"Varicella zoster virus in giant cell arteritis: a review of current medical literature","volume":"43","author":"Ostrowski","year":"2019","journal-title":"Neuroophthalmology"},{"key":"2021010414102206700_CIT0004","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1212\/NXI.0000000000000216","article-title":"VZV in biopsy-positive and -negative giant cell arteritis: analysis of 100+ temporal arteries","volume":"3","author":"Gilden","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"2021010414102206700_CIT0005","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1001\/jamaneurol.2015.2101","article-title":"Analysis of varicella-zoster virus in temporal arteries biopsy positive and negative for giant cell arteritis","volume":"72","author":"Nagel","year":"2015","journal-title":"JAMA Neurol"},{"key":"2021010414102206700_CIT0006","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ajo.2017.12.017","article-title":"Identification of herpes zoster-associated temporal arteritis among cases of giant cell arteritis","volume":"187","author":"Buckingham","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"2021010414102206700_CIT0007","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yexmp.2015.12.007","article-title":"VZV, temporal arteritis, and clinical practice: false positive immunohistochemical detection due to antibody cross-reactivity","volume":"100","author":"Pisapia","year":"2016","journal-title":"Exp Mol Pathol"},{"key":"2021010414102206700_CIT0008","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.semarthrit.2017.02.005","article-title":"No detection of varicella-zoster virus in temporal arteries of patients with giant cell arteritis","volume":"47","author":"Muratore","year":"2017","journal-title":"Semin Arthritis Rheum"},{"key":"2021010414102206700_CIT0009","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.3899\/jrheum.180912","article-title":"Investigating the association of giant cell arteritis with varicella zoster virus in temporal artery biopsies or ascending aortic resections","volume":"46","author":"Solomon","year":"2019","journal-title":"J Rheumatol"},{"key":"2021010414102206700_CIT0010","first-page":"kez556","article-title":"Assessment for varicella zoster virus in patients newly suspected of having giant cell arteritis","author":"Sammel","year":"2019","journal-title":"Rheumatology"},{"key":"2021010414102206700_CIT0011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0022-510X(03)00167-9","article-title":"Absence of detection of varicella-zoster virus DNA in temporal artery biopsies obtained from patients with giant cell arteritis","volume":"215","author":"Kennedy","year":"2003","journal-title":"J Neurol Sci"},{"key":"2021010414102206700_CIT0012","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/viro.2001.1173","article-title":"Varicella-zoster virus gene expression in latently infected rat dorsal root ganglia","volume":"289","author":"Kennedy","year":"2001","journal-title":"Virology"},{"key":"2021010414102206700_CIT0013","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s13365-012-0095-0","article-title":"Immunohistochemical detection of intra-neuronal VZV proteins in snap-frozen human ganglia is confounded by antibodies directed against blood group A1-associated antigens","volume":"18","author":"Ouwendijk","year":"2012","journal-title":"J Neurovirol"},{"key":"2021010414102206700_CIT0014","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.ophtha.2015.04.026","article-title":"Varicella zoster virus in ischemic optic neuropathy","volume":"122","author":"Golas","year":"2015","journal-title":"Ophthalmology"},{"key":"2021010414102206700_CIT0015","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/BF00157878","article-title":"Mast cell immunohistochemistry: non-immunological immunostaining mediated by non-specific F(ab\u2019)2-mast cell secretory granule interaction","volume":"25","author":"Schiltz","year":"1993","journal-title":"Histochem J"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiaa566\/34037590\/jiaa566.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/223\/1\/109\/35388146\/jiaa566.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/223\/1\/109\/35388146\/jiaa566.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T19:15:16Z","timestamp":1609787716000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/223\/1\/109\/5903074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,9,9]]},"published-print":{"date-parts":[[2021,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiaa566","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2020,9,9]]}}}