{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:46Z","timestamp":1792785946120,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Russian Ministry of Science and Higher Education","award":["AAAA-A18-118012390247-0"],"award-info":[{"award-number":["AAAA-A18-118012390247-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atypical mononuclear cells (AM) appear in significant numbers in peripheral blood of patients with Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). We investigated the number and lineage-specific clusters of differentiation (CD) expression of atypical mononuclear cells in 110 children with IM using the anti-CD antibody microarray for panning leukocytes by their surface markers prior to morphology examination. The AM population consisted primarily of CD8+ T cells with a small fraction (0%\u20132% of all lymphocytes) of CD19+ B lymphocytes. AM amount in children with mononucleosis caused by primary EBV infection was significantly higher than for IM caused by EBV reactivation or other viruses and constituted 1%\u201353% of all peripheral blood mononuclear cells compared to 0%\u201311% and 0%\u20138%, respectively. Children failing to recover from classic IM associated with primary EBV infection within 6 months had significantly lower percentage of CD8+ AM compared to patients with normal recovery rate.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa601","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T15:21:31Z","timestamp":1600356091000},"page":"1699-1706","source":"Crossref","is-referenced-by-count":16,"title":["The Nature and Clinical Significance of Atypical Mononuclear Cells in Infectious Mononucleosis Caused by the Epstein-Barr Virus in Children"],"prefix":"10.1093","volume":"223","author":[{"given":"Olga S","family":"Fedyanina","sequence":"first","affiliation":[{"name":"Dmitry Rogachev National Research Centre for Pediatric Hematology, Oncology and Immunology, Moscow, Russia"},{"name":"Centre for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E","family":"Filippova","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Research Centre for Pediatric Hematology, Oncology and Immunology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I","family":"Demina","sequence":"additional","affiliation":[{"name":"Moscow Children\u2019s Hospital named after Z. A. Bashlyaeva, Moscow, Russia"},{"name":"Russian Medical Academy of Continuous Professional Education, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A","family":"Zhuliabina","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Physics, M. V. Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry S","family":"Tikhomirov","sequence":"additional","affiliation":[{"name":"Research Centre for Hematology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V","family":"Filatov","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana A","family":"Chebotareva","sequence":"additional","affiliation":[{"name":"Moscow Children\u2019s Hospital named after Z. A. Bashlyaeva, Moscow, Russia"},{"name":"Russian Medical Academy of Continuous Professional Education, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofya A","family":"Kuznetsova","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Research Centre for Pediatric Hematology, Oncology and Immunology, Moscow, Russia"},{"name":"Centre for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"2021052811194817800_CIT0001","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJM200008173430707","article-title":"Epstein-Barr virus infection","volume":"343","author":"Cohen","year":"2000","journal-title":"N Engl J Med"},{"key":"2021052811194817800_CIT0002","first-page":"1279","article-title":"Epstein-Barr virus infectious 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