{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:56:40Z","timestamp":1773982600873,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","award":["2019\/889177-2"],"award-info":[{"award-number":["2019\/889177-2"]}],"id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The monovalent type 2 oral poliovirus vaccine (mOPV2) stockpile is low. One potential strategy to stretch the existing mOPV2 supply is to administer a reduced dose: 1 drop instead of 2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a randomized, controlled, open-label, noninferiority trial (10% margin) to compared immunogenicity after administration of 1 versus 2 drops of mOPV2. We enrolled 9\u201322-month-old infants from Mocuba district of Mozambique. Poliovirus neutralizing antibodies were measured in serum samples collected before and 1 month after mOPV2 administration. Immune response was defined as seroconversion from seronegative (&amp;lt;1:8) at baseline to seropositive (\u22651:8) after vaccination or boosting titers by \u22654-fold for those with titers between 1:8 and 1:362 at baseline. The trial was registered at anzctr.org.au (no. ACTRN12619000184178p).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We enrolled 378 children, and 262 (69%) completed per-protocol requirements. The immune response of mOPV2 was 53.6% (95% confidence interval, 44.9%\u201362.1%) and 60.6% (52.2%\u201368.4%) in 1-drop and 2-drop recipients, respectively. The noninferiority margin of the 10% was not reached (difference, 7.0%; 95% confidence interval, \u22125.0% to 19.0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A small loss of immunogenicity of reduced mOPV2 was observed. Although the noninferiority target was not achieved, the Strategic Advisory Group of Experts on Immunization recommended the 1-drop strategy as a dose-sparing measure if mOPV2 supplies deteriorate further.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa704","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T04:25:03Z","timestamp":1604636703000},"page":"292-298","source":"Crossref","is-referenced-by-count":8,"title":["Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-7111","authenticated-orcid":false,"given":"Nilsa","family":"de Deus","sequence":"first","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Paulo Ubisse","family":"Capitine","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-9695","authenticated-orcid":false,"given":"Adilson Fernando Loforte","family":"Bauhofer","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"},{"name":"Instituto de Higiene e Medicina Tropical\u2013Universidade Nova de Lisboa , Lisboa , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Marques","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Cassocera","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"},{"name":"Instituto de Higiene e Medicina Tropical\u2013Universidade Nova de Lisboa , Lisboa , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assuc\u00eanio","family":"Chissaque","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"},{"name":"Instituto de Higiene e Medicina Tropical\u2013Universidade Nova de Lisboa , Lisboa , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diocreciano Matias","family":"Bero","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Paulo","family":"Langa","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Manuel","family":"Padama","sequence":"additional","affiliation":[{"name":"Direc\u00e7\u00e3o Provincial de Sa\u00fade da Zamb\u00e9zia , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Visalakshi","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"Polio Eradication Department, World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Steven","family":"Oberste","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepcion F","family":"Estivariz","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Verma","sequence":"additional","affiliation":[{"name":"Polio Eradication Department, World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilesh","family":"Jani","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS) , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Mach","sequence":"additional","affiliation":[{"name":"Polio Eradication Department, World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland W","family":"Sutter","sequence":"additional","affiliation":[{"name":"Polio Eradication Department, World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2022082412281975300_CIT0001","author":"Global Polio Eradication Initiative"},{"key":"2022082412281975300_CIT0002","author":"Centers for Disease Control and 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