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Methods are needed to distinguish aMCI-associated from HAND-associated impairment in people with HIV (PWH). We developed a neuropsychological method of identifying aMCI in PWH and tested this by relating AD neuropathology (\u03b2-amyloid, phospho-Tau) to aMCI versus HAND classification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seventy-four HIV-positive cases (aged 50\u221268 years) from the National NeuroAIDS Tissue Consortium had neurocognitive data within 1 year of death and data on \u03b2-amyloid and phospho-Tau pathology in frontal brain tissue. High aMCI risk was defined as impairment (&amp;lt;1.0 SD below normative mean) on 2 of 4 delayed recall or recognition outcomes from a verbal and nonverbal memory test (at least 1 recognition impairment required). Differences in \u03b2-amyloid and phospho-Tau by aMCI and HAND classification were examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>High aMCI risk was more common in HAND (69.0%) versus no HAND (37.5%) group. \u03b2-amyloid pathology was 4.75 times more likely in high versus low aMCI risk group. Phospho-Tau pathology did not differ between aMCI groups. Neither neuropathological feature differed by HAND status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Amnestic mild cognitive impairment criteria that include recognition impairment may help to detect AD-like cognitive\/biomarker profiles among PWH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa760","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T04:37:22Z","timestamp":1607575042000},"page":"435-442","source":"Crossref","is-referenced-by-count":25,"title":["Distinguishing Amnestic Mild Cognitive Impairment From HIV-Associated Neurocognitive Disorders"],"prefix":"10.1093","volume":"224","author":[{"given":"Erin E","family":"Sundermann","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Bondi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, California, USA"},{"name":"Veterans Affairs San Diego Healthcare System, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, California, USA"},{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Gouaux","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raeanne C","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virawudh","family":"Soontornniyomkij","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"2021080216301656900_CIT0001","author":"Centers for Disease Control and 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