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In silico studies were performed using X-ray resolved dimer constructions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The DQA1*01, DQA1*05, DQB1*02, or DQB1*06 genotypes\/haplotypes and DQA1\/DQB1 haplotypes that encode the putative DQA1\/DQB1 dimers were overrepresented in the whole group of patients and in patients exhibiting peripheral neurological spectrum disorders (PSD) or encephalitis spectrum disorders (ESD). The DRB1*04, DRB1*13, and DQA1*03 allele groups protected against arbovirus neurological manifestation, being underrepresented in whole group of patients and ESD and PSD groups. Genetic and in silico studies revealed that DQA1\/DQB1 dimers (1) were primarily associated with susceptibility to arbovirus infections; (2) can bind to a broad range of ZIKV peptides (235 of 1878 peptides, primarily prM and NS2A); and (3) exhibited hydrophilic and highly positively charged grooves when compared to the DRA1\/DRB1 cleft. The protective dimer (DRA1\/DRB1*04) bound a limited number of ZIKV peptides (40 of 1878 peptides, primarily prM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Protective haplotypes may recognize arbovirus peptides more specifically than susceptible haplotypes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa764","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T06:15:31Z","timestamp":1607753731000},"page":"517-525","source":"Crossref","is-referenced-by-count":1,"title":["Differential Frequencies of <i>HLA-DRB1<\/i>, <i>DQA1<\/i>, and <i>DQB1<\/i> Alleles and Haplotypes Are Observed in the Arbovirus-Related Neurological Syndromes"],"prefix":"10.1093","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-4719","authenticated-orcid":false,"given":"Paulin","family":"Sonon","sequence":"first","affiliation":[{"name":"Immunology Department, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L\u00facia","family":"Brito Ferreira","sequence":"additional","affiliation":[{"name":"Hospital da Restaura\u00e7\u00e3o Governador Paulo Guerra, Recife, Pernambuco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Santos Almeida","sequence":"additional","affiliation":[{"name":"Immunology Department, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neifi Hassan","family":"Saloum Deghaide","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Medical 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