{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T09:29:08Z","timestamp":1780824548638,"version":"3.54.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL116275"],"award-info":[{"award-number":["T32 HL116275"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ebola virus disease (EVD) supportive care strategies are largely guided by retrospective observational research. This study investigated the effect of EVD supportive care algorithms on duration of survival in a controlled nonhuman primate (NHP) model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen rhesus macaques were challenged intramuscularly with a target dose of Ebola virus (1000 plaque-forming units; Kikwit). NHPs were allocated to intensive care unit (ICU)\u2013like algorithms (n\u2005=\u20057), intravenous fluids plus levofloxacin (n\u2005=\u20052), or a control group (n\u2005=\u20055). The primary outcome measure was duration of survival, and secondary outcomes included changes in clinical laboratory values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Duration of survival was not significantly different between the pooled ICU-like algorithm and control groups (8.2 vs 6.9 days of survival; hazard ratio; 0.50; P\u2005=\u2005.25). Norepinephrine was effective in transiently maintaining baseline blood pressure. NHPs treated with ICU-like algorithms had delayed onset of liver and kidney injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While an obvious survival difference was not observed with ICU-like care, clinical observations from this model may aid in EVD supportive care NHP model refinement.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiaa781","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T12:20:30Z","timestamp":1608380430000},"page":"632-642","source":"Crossref","is-referenced-by-count":5,"title":["Intensive Care Unit\u2013Like Care of Nonhuman Primates with Ebola Virus Disease"],"prefix":"10.1093","volume":"224","author":[{"given":"Paul W","family":"Blair","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"},{"name":"Austere Environments Consortium for Enhanced Sepsis Outcomes, Henry M. 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