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On-ART sCD14 and C-reactive protein concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa787","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T20:12:24Z","timestamp":1609186344000},"page":"673-678","source":"Crossref","is-referenced-by-count":8,"title":["Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy"],"prefix":"10.1093","volume":"224","author":[{"given":"Stefanie","family":"Kroeze","sequence":"first","affiliation":[{"name":"Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Department of Experimental Immunology, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Center, University of 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