{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:27:27Z","timestamp":1790872047262,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006507","name":"Oswaldo Cruz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rene Rachou Institute"},{"name":"Brazilian Council for Scientific and Technological Development"},{"name":"Nacional de Ci\u00eancia e Tecnologia\u2013Entomologia Molecular"},{"name":"Comiss\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Aedes aegypti is a highly competent vector in the transmission of arboviruses, such as chikungunya, dengue, Zika, and yellow fever viruses, and causes single and coinfections in the populations of tropical countries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The infection rate, viral abundance (VA), vector competence (VC), disseminated infection, and survival rate were recorded after single and multiple infections of the vector with 15 combinations of chikungunya, dengue, Zika, and yellow fever arboviruses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Infection rates were 100% in all single and multiple infection experiments, except in 1 triple coinfection that presented a rate of 50%. The VC and disseminated infection rate varied from 100% (in single and quadruple infections) to 40% (in dual and triple infections). The dual and triple coinfections altered the VC and\/or VA of \u22651 arbovirus. The highest viral VAs were detected for a single infection with chikungunya. The VAs in quadruple infections were similar when compared with each respective single infection. A decrease in survival rates was observed in a few combinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A. aegypti was able to host all single and multiple arboviral coinfections. The interference of the chikungunya virus suggests that distinct arbovirus families may have a significant role in complex coinfections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab066","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T21:41:33Z","timestamp":1612388493000},"page":"101-108","source":"Crossref","is-referenced-by-count":18,"title":["Brazilian <i>Aedes aegypti<\/i> as a Competent Vector for Multiple Complex Arboviral Coinfections"],"prefix":"10.1093","volume":"224","author":[{"given":"Nilton Barnab\u00e9","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Laboratory of Medical Entomology, Ren\u00e9 Rachou Institute\u2013FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Soares Maia","family":"Godoy","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Entomology, Ren\u00e9 Rachou Institute\u2013FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Silva","family":"Orfano","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Entomology, Ren\u00e9 Rachou Institute\u2013FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Aparecida","family":"Chaves","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisas Cl\u00ednicas Carlos Borborema, Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Bonif\u00e1cio","family":"Campolina","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Entomology, Ren\u00e9 Rachou Institute\u2013FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno dos Anjos","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Entomology, Ren\u00e9 Rachou Institute\u2013FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edza dos Santos","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Entomology, Ren\u00e9 Rachou Institute\u2013FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno Melo","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Eric","family":"Norris","sequence":"additional","affiliation":[{"name":"W. 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