{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:16:55Z","timestamp":1789676215648,"version":"4.0.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"UK Medical Research Council Centre","award":["MR\/N022556\/1"],"award-info":[{"award-number":["MR\/N022556\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection worldwide, has been widely researched for its involvement in many disease pathologies in the reproductive tract, including pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility. Recent findings, through the efforts to understand the pathogenesis of CT, suggest that CT can induce the process of epithelial-to-mesenchymal transition (EMT) through epigenetic changes in the epithelium of the female reproductive tract. This literature review aims to analyze the evidence for CT\u2019s ability to promote EMT and to pinpoint the areas that merit further investigation.<\/jats:p>","DOI":"10.1093\/infdis\/jiab088","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T12:33:09Z","timestamp":1612873989000},"page":"S128-S136","source":"Crossref","is-referenced-by-count":15,"title":["Is There a Hidden Burden of Disease as a Result of Epigenetic Epithelial-to-Mesenchymal Transition Following <i>Chlamydia trachomatis<\/i> Genital Tract Infection?"],"prefix":"10.1093","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-8332","authenticated-orcid":false,"given":"Patrick J","family":"Horner","sequence":"first","affiliation":[{"name":"Population Health Sciences, University of Bristol, Bristol, United Kingdom"},{"name":"National Institute for Health Research Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9656-493X","authenticated-orcid":false,"given":"Andrew W","family":"Horne","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"2021081606004692100_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta20220","article-title":"The natural history of Chlamydia trachomatis infection in women: a multi-parameter evidence synthesis","volume":"20","author":"Price","year":"2016","journal-title":"Health Technol Assess"},{"key":"2021081606004692100_CIT0002","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/CMR.00035-15","article-title":"Human and pathogen factors associated with Chlamydia trachomatis-related infertility in women","volume":"28","author":"Menon","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"2021081606004692100_CIT0003","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00007435-199207000-00001","article-title":"Pelvic inflammatory disease and fertility. 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