{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:05:47Z","timestamp":1789088747180,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding and infectivity, we estimated SARS-CoV-2 RNA shedding duration, described participant characteristics associated with the first negative rRT-PCR test (resolution), and determined if replication-competent viruses was recoverable \u226510 days after symptom onset.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected serial nasopharyngeal specimens from 109 individuals with rRT-PCR\u2013confirmed COVID-19 in Utah and Wisconsin. We calculated viral RNA shedding resolution probability using the Kaplan-Meier estimator and evaluated characteristics associated with shedding resolution using Cox proportional hazards regression. We attempted viral culture for 35 rRT-PCR\u2013positive nasopharyngeal specimens collected \u226510 days after symptom onset.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The likelihood of viral RNA shedding resolution at 10 days after symptom onset was approximately 3%. Time to shedding resolution was shorter among participants aged &amp;lt;18 years (adjusted hazards ratio [aHR], 3.01; 95% confidence interval [CI], 1.6\u20135.6) and longer among those aged \u226550 years (aHR, 0.50; 95% CI, .3\u2013.9) compared to participants aged 18\u201349 years. No replication-competent viruses were recovered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although most patients were positive for SARS-CoV-2 for \u226510 days after symptom onset, our findings suggest that individuals with mild to moderate COVID-19 are unlikely to be infectious \u226510 days after symptom onset.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab107","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T06:09:05Z","timestamp":1613628545000},"page":"1362-1371","source":"Crossref","is-referenced-by-count":97,"title":["Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness: A Cohort Study of Individuals With 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