{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:19:09Z","timestamp":1791839949229,"version":"4.3.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust and the Royal Society","award":["099953\/Z\/12\/Z"],"award-info":[{"award-number":["099953\/Z\/12\/Z"]}]},{"name":"Wellcome Trust Investigator Award","award":["107964\/Z\/15\/Z"],"award-info":[{"award-number":["107964\/Z\/15\/Z"]}]},{"name":"Biotechnology and Biological Sciences Research Council Discovery Fellowship","award":["BB\/T009543\/1"],"award-info":[{"award-number":["BB\/T009543\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an immunocompromised patient. The mutated form of Dectin-2 was weakly expressed, did not form clusters at\/near the cell surface and was functionally defective. Peripheral blood mononuclear cells from this patient were unable to mount a cytokine (tumor necrosis factor, interleukin 6) response to Aspergillus fumigatus, and this first identified Dectin-2\u2013deficient patient died of complications of invasive aspergillosis.<\/jats:p>","DOI":"10.1093\/infdis\/jiab145","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:24:25Z","timestamp":1615854265000},"page":"1219-1224","source":"Crossref","is-referenced-by-count":22,"title":["A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis"],"prefix":"10.1093","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-2465","authenticated-orcid":false,"given":"James S","family":"Griffiths","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"},{"name":"Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Lewis","family":"White","sequence":"additional","affiliation":[{"name":"Public Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena A","family":"Czubala","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Simonazzi","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"},{"name":"United Kingdom Dementia Research Institute at Cardiff, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariolina","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiysha","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"},{"name":"United Kingdom Dementia Research Institute at Cardiff, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre J","family":"Rizkallah","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gurney","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo M","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian R","family":"Naglik","sequence":"additional","affiliation":[{"name":"Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Ingram","sequence":"additional","affiliation":[{"name":"University Hospital of Wales, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom"},{"name":"University Hospital of Wales, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L","family":"van de Veerdonk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Barnes","sequence":"additional","affiliation":[{"name":"University Hospital of Wales, Cardiff, United 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