{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:05:07Z","timestamp":1791813907023,"version":"4.3.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:00:00Z","timestamp":1620518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","award":["K08-AI151253-01"],"award-info":[{"award-number":["K08-AI151253-01"]}],"id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","award":["U54-HD090259"],"award-info":[{"award-number":["U54-HD090259"]}],"id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Platelets are a critical immune defense against Staphylococcus aureus bloodstream infections. Staphylococcus aureus \u03b1-toxin is a virulence factor that decreases platelet viability and accelerates platelet clearance. It has been shown that ticagrelor blocks \u03b1-toxin\u2013mediated platelet injury and resulting thrombocytopenia, protecting mice in a lethal S. aureus sepsis model. We now present the use of ticagrelor as adjunctive therapy in a patient with a S. aureus endovascular infection and thrombocytopenia, associated with restoration of platelet count and bacteremia clearance. Ticagrelor enhanced platelet killing of the S. aureus bloodstream isolate from the treated patient in vitro.<\/jats:p>","DOI":"10.1093\/infdis\/jiab146","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T12:09:08Z","timestamp":1616069348000},"page":"1566-1569","source":"Crossref","is-referenced-by-count":35,"title":["Ticagrelor Increases Platelet-Mediated <i>Staphylococcus aureus<\/i> Killing, Resulting in Clearance of Bacteremia"],"prefix":"10.1093","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-278X","authenticated-orcid":false,"given":"Erlinda R","family":"Ulloa","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of California, Irvine School of Medicine, Irvine, California, USA"},{"name":"Division of Infectious Disease, Children\u2019s Hospital of Orange County, Orange, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Sharp Rees-Stealy Medical Group, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Nizet","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Children\u2019s Hospital of Orange County, Orange, California, USA"},{"name":"Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sakoulas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Diego 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