{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T11:31:11Z","timestamp":1742643071142},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The 10-valent conjugate vaccine (PCV10) was introduced into the Extended Program on Immunization in Madagascar. We assessed the impact of PCV10 on the targeted pneumococcal serotypes among children &amp;lt; 5 years of age at Centre Hospitalier Universitaire M\u00e8re Enfant Tsaralal\u00e0na.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Between 2012 and December 2018, cerebrospinal fluid (CSF) samples were collected and tested for S. pneumoniae by culture, and antigen tests. The Sentinel Site Laboratory (SSL) referred available CSF samples to the Regional Reference Laboratory (RRL) for real-time polymerase chain reaction confirmatory testing and serotyping.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 3616 CSF specimens were collected. The SSL referred 2716 to the RRL; 125 were positive for S. pneumoniae. At the RRL, 115 samples that tested positive for S. pneumoniae were serotyped; PCV10 serotypes accounted for 20%. Compared to the pre-PCV period, the proportion of S. pneumoniae detected declined from 22% to 6.6%, (P &amp;lt; .05), the proportion of PCV10 serotypes as the cause of pneumococcal meningitis cases declined by 26% following vaccine introduction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our findings, PCV10 introduction resulted in a decline of meningitis caused by S. pneumoniae and PCV10 vaccine serotypes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab226","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:14:30Z","timestamp":1619205270000},"page":"S285-S292","source":"Crossref","is-referenced-by-count":2,"title":["Decline in Vaccine-Type <i>Streptococcus pneumoniae<\/i> Serotypes Following Pneumococcal Conjugate Vaccine Introduction in Madagascar"],"prefix":"10.1093","volume":"224","author":[{"given":"Julia L","family":"Raboba","sequence":"first","affiliation":[{"name":"Department of Child Health, Teaching Hospital, Centre Hospitalier Universitaire M\u00e8re Enfant Tsaral\u00e0lana, Antananarivo, Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vonintsoa L","family":"Rahajamanana","sequence":"additional","affiliation":[{"name":"Department of Child Health, Teaching Hospital, Centre Hospitalier Universitaire M\u00e8re Enfant Tsaral\u00e0lana, Antananarivo, Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilson P R","family":"Andriatahirintsoa","sequence":"additional","affiliation":[{"name":"Teaching Hospital, Centre Hospitalier Universitaire Anosiala, Antananarivo, Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainamalala C","family":"Razafindrakoto","sequence":"additional","affiliation":[{"name":"Department of Child Health, Teaching Hospital, Centre Hospitalier Universitaire M\u00e8re Enfant Tsaral\u00e0lana, Antananarivo, Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andry M","family":"Andrianarivelo","sequence":"additional","affiliation":[{"name":"Teaching Hospital, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcellin","family":"Nimpa Mengouo","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office, Antananarivo, Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolande","family":"Vuo Masembe","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office, Antananarivo, Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goitom G","family":"Weldegebriel","sequence":"additional","affiliation":[{"name":"World Health Organization Inter-Country Support Team East and Southern Africa, Harare, 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