{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:50:12Z","timestamp":1790009412627,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["404138\/2012-8"],"award-info":[{"award-number":["404138\/2012-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03452-13"],"award-info":[{"award-number":["APQ-03452-13"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Apoio a Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["13\/21719-3"],"award-info":[{"award-number":["13\/21719-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increased levels of inflammatory cytokines are associated with severe dengue evolution, but the source of such hypercytokinemia is elusive. We investigated the contribution of innate lymphocytes, innate lymphoid cells (ILCs), and natural killer (NK) cells in cytokine production in early dengue infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peripheral blood mononuclear cells of individuals with dengue without warning signs (DWS\u2013) and dengue with warning signs and severe dengue (SD) presentation combined (DWS+) were obtained between 2 and 7 days since fever onset and submitted to flow cytometry without specific antigen stimulation to evaluate cytokines in ILC and NK cell subpopulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ILCs and NK cells were found to be important sources of cytokines during dengue. ILCs of the DWS+\/SD group displayed higher production of interferon gamma (IFN-\u03b3) and interleukin (IL) 4\/IL-13 when compared to DWS\u2013 individuals. On the other hand, NK Eomes+ cells of DWS\u2013 patients displayed higher IFN-\u03b3 production levels compared with the DWS+\/SD group. Interestingly, when NK cells were identified by CD56 expression, DWS+\/SD displayed higher frequency of IL-17 production compared with the DWS\u2013 group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that ILCs and NK cells are important sources of inflammatory cytokines during acute dengue infection and display distinct profiles associated with different clinical forms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiab312","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T15:11:00Z","timestamp":1623251460000},"page":"84-93","source":"Crossref","is-referenced-by-count":20,"title":["Type 1 Innate Lymphoid Cell and Natural Killer Cells Are Sources of Interferon-\u03b3 and Other Inflammatory Cytokines Associated With Distinct Clinical Presentation in Early Dengue Infection"],"prefix":"10.1093","volume":"225","author":[{"given":"Iracema Luisa","family":"Quintino-de-Carvalho","sequence":"first","affiliation":[{"name":"Departamento de Microbiologia, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Helena","family":"Gon\u00e7alves-Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia e Bioqu\u00edmica, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Faria Ramos","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia e Bioqu\u00edmica, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Henrique Gon\u00e7alves","family":"de Aguiar Milhim","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto , S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00daltimo Lib\u00e2nio","family":"Da Costa","sequence":"additional","affiliation":[{"name":"Secretaria Municipal de Sa\u00fade , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rika Gon\u00e7alves","family":"Santos","sequence":"additional","affiliation":[{"name":"Secretaria Municipal de Sa\u00fade , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Lacerda","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto , S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helton","family":"Da Costa Santiago","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia e Bioqu\u00edmica, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"2026041420074913300_CIT0001","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"2026041420074913300_CIT0002","volume-title":"Dengue: guidelines for diagnosis, treatment, prevention and control\u2014new edition","author":"World Health 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