{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:23:11Z","timestamp":1782519791461,"version":"3.54.5"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI112524"],"award-info":[{"award-number":["AI112524"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The fusion (F) glycoprotein of respiratory syncytial virus (RSV) represents the major neutralizing antigen, and antibodies against the pre-F conformation have the most potent neutralizing activity. This study aimed to assess the correlation between maternal antibody titers against the pre-F, post-F, and G glycoproteins and the child\u2019s risk of developing severe RSV bronchiolitis early in infancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We identified previously healthy term infants &amp;lt;3 months of age hospitalized with RSV bronchiolitis from December 2015 to March 2016. We measured IgG antibody titers to pre-F, post-F, and G proteins in maternal sera obtained at 9\u201312 weeks of pregnancy of these hospitalized infants\u2019 mothers (n\u2005=\u200594) and compared them with serum antibody titers of control pregnant mothers (n\u2005=\u2005130) whose children were not hospitalized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All maternal samples (n\u2005=\u2005224) had detectable pre-F antibodies. Pre-F antibody titers were significantly lower in mothers whose infants were hospitalized with RSV bronchiolitis compared with those mothers whose infants were not hospitalized (23.9 [range (or antibody titer range), 1.4\u2013273.7] \u00b5g\/L vs 30.6 [XXX, 3.4\u2013220.0] \u00b5g\/L; P\u2005=\u2005.0026). There were no significant differences in maternal post-F and G antibody titers between hospitalized and nonhospitalized infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings indicate that maternal pre-F antibodies are fundamental for providing immune protection to the infant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab315","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T11:16:24Z","timestamp":1623410184000},"page":"1189-1196","source":"Crossref","is-referenced-by-count":34,"title":["Respiratory Syncytial Virus (RSV)\u2013Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants"],"prefix":"10.1093","volume":"225","author":[{"given":"Karoliina","family":"Koivisto","sequence":"first","affiliation":[{"name":"Helsinki University Hospital and University of Helsinki, Children\u2019s Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital and University of Helsinki, Children\u2019s Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-8006","authenticated-orcid":false,"given":"Asuncion","family":"Mejias","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Capella Gonzalez","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ye","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mertz","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Peeples","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Ramilo","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Sax\u00e9n","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital and University of Helsinki, Children\u2019s Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"2022040117550394200_CIT0001","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0140-6736(17)30938-8","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to 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