{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:01:26Z","timestamp":1775340086635,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Brazilian Council for Scientific and Technological Development","award":["40181\/2012-0"],"award-info":[{"award-number":["40181\/2012-0"]}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["06201954\/2015"],"award-info":[{"award-number":["06201954\/2015"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Emerging evidence suggests that the interleukin (IL) 17\/ IL-23 axis may play a role in the pathogenesis of leishmaniasis. Our aim was to investigate whether the IL-23R variant rs11805303 is a risk factor for the development of cutaneous leishmaniasis (CL) in Leishmania guyanensis\u2013infected individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We genotyped by polymerase chain reaction\u2013restriction fragment length polymorphism the rs11805303 C\/T in 828 patients with CL and 806 healthy individuals. Plasma tumor necrosis factor\u2013\u03b1, IL-6, interferon-\u03b3, IL-1\u03b2, and IL-17 were measured with the Bioplex assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of the genotypes differed between patients with CL and healthy controls with a common odds ratio of 1.78 (P\u2005=\u20052.2\u2005\u00d7\u200510\u201311) for the disease-associated T allele. Leishmania guyanensis\u2013infected individuals homozygous for the T allele show a 200% increased risk of progressing to disease development, with a 95% confidence interval ranging from 81% to 400% (P\u2005=\u20059.9\u2005\u00d7\u200510\u20136) in comparison to individuals homozygous for the C allele. Males homozygous for the T allele have higher plasma levels of IL-17 compared with heterozygous or homozygous CC individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present association of the IL-23R variant rs11805303 with the development of CL suggests that the IL-17\/IL-23 axis may play an important role in the pathogenesis of CL.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiab320","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T19:12:35Z","timestamp":1623784355000},"page":"163-171","source":"Crossref","is-referenced-by-count":6,"title":["<i>IL-23R<\/i>Variant rs11805303 Is Associated With Susceptibility to the Development of Cutaneous Leishmaniasis in<i>Leishmania guyanensis<\/i>\u2013Infected Individuals"],"prefix":"10.1093","volume":"225","author":[{"given":"Lener","family":"Santos da Silva","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Viera Dourado, 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