{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:05:34Z","timestamp":1790827534639,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French National Agency for Research on AIDS and Emerging Infectious Diseases"},{"name":"ANRS-MIE"},{"name":"AC43)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to assess the kinetics of drug-resistant viral variants (DRVs) harboring the M184V mutation in proviral DNA of long-term virally suppressed patients, and factors associated with DRV persistence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human immunodeficiency virus (HIV) DNA from blood cells stored in 2016 and 2019 was sequenced using Sanger and ultradeep sequencing (SS and UDS; detection threshold 1%) in antiretroviral therapy (ART)-treated patients with HIV RNA\u2005&amp;lt;\u200550 copies\/mL for at least 5 years, with past M184V mutation documented in HIV RNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 79 patients, by combining SS and UDS, M184V was found to be absent in 26\/79 (33%) patients and persistent in 53\/79 (67%). M184V-positive patients had a longer history of ART, lower CD4 nadir, and higher pretherapeutic HIV RNA. Among 37 patients with viral sequences assessed by UDS, the proportion of M184V-positive DRVs significantly decreased between 2016 and 2019 (40% vs 14%, P\u2005=\u2005.005). The persistence of M184V was associated with duration and level of HIV RNA replication under lamivudine\/emtricitabine (3TC\/FTC; P\u2005=\u2005.0009 and P\u2005=\u2005.009, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While it decreased over time in HIV DNA, M184V mutation was more frequently persistent in HIV DNA of more treatment-experienced patients with longer past replication under 3TC\/FTC.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiab413","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T20:03:18Z","timestamp":1629230598000},"page":"502-509","source":"Crossref","is-referenced-by-count":28,"title":["Kinetics of Archived M184V Mutation in Treatment-Experienced Virally Suppressed HIV-Infected Patients"],"prefix":"10.1093","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-0101","authenticated-orcid":false,"given":"Romain","family":"Palich","sequence":"first","affiliation":[{"name":"Sorbonne University, Infectious Diseases Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"},{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Teyssou","sequence":"additional","affiliation":[{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Sayon","sequence":"additional","affiliation":[{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-0010","authenticated-orcid":false,"given":"Basma","family":"Abdi","sequence":"additional","affiliation":[{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathia","family":"Soulie","sequence":"additional","affiliation":[{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6345-497X","authenticated-orcid":false,"given":"Lise","family":"Cuzin","sequence":"additional","affiliation":[{"name":"Centre d\u2019Epid\u00e9miologie et de Recherche en Sant\u00e9 des Populations, Toulouse University, INSERM UMR1295, Universit\u00e9 Paul Sabatier, Toulouse, France"},{"name":"Infectious Diseases Department, Martinique University Hospital, Fort-de-France, MartiniqueFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Tubiana","sequence":"additional","affiliation":[{"name":"Sorbonne University, Infectious Diseases Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Valantin","sequence":"additional","affiliation":[{"name":"Sorbonne University, Infectious Diseases Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luminita","family":"Schneider","sequence":"additional","affiliation":[{"name":"Sorbonne University, Infectious Diseases Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Seang","sequence":"additional","affiliation":[{"name":"Sorbonne University, Infectious Diseases Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Wirden","sequence":"additional","affiliation":[{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7378-2179","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Pourcher","sequence":"additional","affiliation":[{"name":"Sorbonne University, Infectious Diseases Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Katlama","sequence":"additional","affiliation":[{"name":"Sorbonne University, Infectious Diseases Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Calvez","sequence":"additional","affiliation":[{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Genevi\u00e8ve","family":"Marcelin","sequence":"additional","affiliation":[{"name":"Sorbonne University, Virology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Pierre Louis Epidemiology and Public Health Institute, INSERM 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"2022020201070544400_CIT0001","first-page":"979","article-title":"Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1","volume":"10","author":"Turner","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"2022020201070544400_CIT0002","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/00002030-200405210-00008","article-title":"The lymphocyte HIV reservoir in patients on long-term HAART is a memory of virus evolution","volume":"18","author":"Lambotte","year":"2004","journal-title":"AIDS"},{"key":"2022020201070544400_CIT0003","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/infdis\/171.6.1411","article-title":"Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)","volume":"171","author":"Schuurman","year":"1995","journal-title":"J Infect Dis"},{"key":"2022020201070544400_CIT0004","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1097\/00002030-200111090-00016","article-title":"Re-occurrence of HIV-1 drug mutations after treatment re-initiation following interruption in patients with multiple treatment failure","volume":"15","author":"Delaugerre","year":"2001","journal-title":"AIDS"},{"key":"2022020201070544400_CIT0005","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/315444","article-title":"Reduction in human immunodeficiency virus type 1 mutations associated with drug resistance after initiating new therapeutic regimens in pretreated patients","volume":"181","author":"Devereux","year":"2000","journal-title":"J Infect Dis"},{"key":"2022020201070544400_CIT0006","doi-asserted-by":"crossref","first-page":"e384","DOI":"10.1016\/S2352-3018(17)30069-3","article-title":"Boosted protease inhibitor monotherapy versus boosted protease inhibitor plus lamivudine dual therapy as second-line maintenance treatment for HIV-1-infected patients in sub-Saharan Africa (ANRS12 286\/MOBIDIP): a multicentre, randomised, parallel, open-label, superiority trial","volume":"4","author":"Ciaffi","year":"2017","journal-title":"Lancet HIV"},{"key":"2022020201070544400_CIT0007","doi-asserted-by":"crossref","first-page":"ofz330","DOI":"10.1093\/ofid\/ofz330","article-title":"Impact of the M184V\/I mutation on the efficacy of abacavir\/lamivudine\/dolutegravir therapy in HIV treatment-experienced patients","volume":"6","author":"Olearo","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"2022020201070544400_CIT0008","doi-asserted-by":"crossref","first-page":"ofy113","DOI":"10.1093\/ofid\/ofy113","article-title":"Impact of the M184V resistance mutation on virological efficacy and durability of lamivudine-based dual antiretroviral regimens as maintenance therapy in individuals with suppressed HIV-1 RNA: a cohort study","volume":"5","author":"Gagliardini","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"2022020201070544400_CIT0009","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/jac\/dkaa479","article-title":"Long-term efficacy of dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: week 96 results of ART-PRO pilot study","volume":"76","author":"Rial-Crestelo","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"2022020201070544400_CIT0010","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1468-1293.2012.01002.x","article-title":"Comparison of resistance mutation patterns in historical plasma HIV RNA genotypes with those in current proviral HIV DNA genotypes among extensively treated patients with suppressed replication","volume":"13","author":"Delaugerre","year":"2012","journal-title":"HIV Med"},{"key":"2022020201070544400_CIT0011","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/jac\/dkq544","article-title":"Historical HIV-RNA resistance test results are more informative than proviral DNA genotyping in cases of suppressed or residual viraemia","volume":"66","author":"Wirden","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"2022020201070544400_CIT0012","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1093\/jac\/dky130","article-title":"Dynamics of drug resistance-associated mutations in HIV-1 DNA reverse transcriptase sequence during effective ART","volume":"73","author":"Nouchi","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2022020201070544400_CIT0013","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/jac\/dkv395","article-title":"Drug resistance and tropism as markers of the dynamics of HIV-1 DNA quasispecies in blood cells of heavily pretreated patients who achieved sustained virological suppression","volume":"71","author":"Gantner","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2022020201070544400_CIT0014","doi-asserted-by":"crossref","first-page":"6824","DOI":"10.1128\/AAC.01490-15","article-title":"HIV drug resistance testing by high-multiplex \u201cwide\u201d sequencing on the MiSeq instrument","volume":"59","author":"Lapointe","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2022020201070544400_CIT0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jmv.21390","article-title":"LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)","volume":"81","author":"Avettand-F\u00e8no\u00ebl","year":"2009","journal-title":"J Med Virol"},{"key":"2022020201070544400_CIT0016","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/cid\/ciy382","article-title":"Ultrasensitive human immunodeficiency virus type 1 viral load as a marker of treatment choice for simplification strategies","volume":"67","author":"Lambert-Niclot","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2022020201070544400_CIT0017","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1468-1293.2009.00719.x","article-title":"A large French prospective cohort of HIV-infected patients: the Nadis Cohort","volume":"10","author":"Pugliese","year":"2009","journal-title":"HIV Med"},{"key":"2022020201070544400_CIT0018","doi-asserted-by":"crossref","first-page":"e00105-18","DOI":"10.1128\/JCM.00105-18","article-title":"Comparison of an in vitro diagnostic next-generation sequencing assay with Sanger sequencing for HIV-1 genotypic resistance testing","volume":"56","author":"Tzou","year":"2018","journal-title":"J Clin Microbiol"},{"key":"2022020201070544400_CIT0019","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/v12060617","article-title":"Next-generation sequencing for HIV drug resistance testing: laboratory, clinical, and implementation considerations","volume":"12","author":"\u00c1vila-R\u00edos","year":"2020","journal-title":"Viruses"},{"key":"2022020201070544400_CIT0020","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/infdis\/jix430","article-title":"The role of HIV-1 drug-resistant minority variants in treatment failure","volume":"216","author":"Stella-Ascariz","year":"2017","journal-title":"J Infect Dis"},{"key":"2022020201070544400_CIT0021","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1001\/jama.2011.375","article-title":"Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis","volume":"305","author":"Li","year":"2011","journal-title":"JAMA"},{"key":"2022020201070544400_CIT0022","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1073\/pnas.1105688108","article-title":"Role of low-frequency HIV-1 variants in failure of nevirapine-containing antiviral therapy in women previously exposed to single-dose nevirapine","volume":"108","author":"Boltz","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022020201070544400_CIT0023","doi-asserted-by":"crossref","first-page":"e46334","DOI":"10.1371\/journal.pone.0046334","article-title":"A genotypic test for HIV-1 tropism combining Sanger sequencing with ultradeep sequencing predicts virologic response in treatment-experienced patients","volume":"7","author":"Kagan","year":"2012","journal-title":"PLoS One"},{"key":"2022020201070544400_CIT0024","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/QAD.0000000000000267","article-title":"Comparison of ultra-deep versus Sanger sequencing detection of minority mutations on the HIV-1 drug resistance interpretations after virological failure","volume":"28","author":"Mohamed","year":"2014","journal-title":"AIDS"},{"key":"2022020201070544400_CIT0025","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1093\/jac\/dky315","article-title":"Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia","volume":"73","author":"Rodriguez","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2022020201070544400_CIT0026","doi-asserted-by":"crossref","first-page":"104207","DOI":"10.1016\/j.jcv.2019.104207","article-title":"Routine drug resistance testing in HIV-1 proviral DNA, using an automated next- generation sequencing assay","volume":"121","author":"Alidjinou","year":"2019","journal-title":"J Clin Virol"},{"key":"2022020201070544400_CIT0027","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/CMR.00015-16","article-title":"Total HIV-1 DNA, a marker of viral reservoir dynamics with clinical implications","volume":"29","author":"Avettand-F\u00e8no\u00ebl","year":"2016","journal-title":"Clin Microbiol Rev"},{"key":"2022020201070544400_CIT0028","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1097\/QAD.0000000000001948","article-title":"HIV DNA levels and decay in a cohort of 111 long-term virally suppressed patients","volume":"32","author":"Golob","year":"2018","journal-title":"AIDS"},{"key":"2022020201070544400_CIT0029","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1038\/s41467-019-10884-9","article-title":"Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART","volume":"10","author":"Bachmann","year":"2019","journal-title":"Nat Commun"},{"key":"2022020201070544400_CIT0030","article-title":"Intact proviral DNA levels decline in people with HIV on antiretroviral therapy,","author":"Gandhi"},{"key":"2022020201070544400_CIT0031","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.4156","article-title":"Defective proviruses rapidly accumulate during acute HIV-1 infection","volume":"22","author":"Bruner","year":"2016","journal-title":"Nat Med"},{"key":"2022020201070544400_CIT0032","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1073\/pnas.1609057113","article-title":"Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy","volume":"113","author":"Imamichi","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022020201070544400_CIT0033","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","article-title":"Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure","volume":"155","author":"Ho","year":"2013","journal-title":"Cell"},{"key":"2022020201070544400_CIT0034","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm880","article-title":"Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells","volume":"9","author":"Siliciano","year":"2003","journal-title":"Nat Med"},{"key":"2022020201070544400_CIT0035","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nm.1972","article-title":"HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation","volume":"15","author":"Chomont","year":"2009","journal-title":"Nat Med"},{"key":"2022020201070544400_CIT0036","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature16933","article-title":"Persistent HIV-1 replication maintains the tissue reservoir during therapy","volume":"530","author":"Lorenzo-Redondo","year":"2016","journal-title":"Nature"},{"key":"2022020201070544400_CIT0037","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.0800050105","article-title":"Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy","volume":"105","author":"Palmer","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022020201070544400_CIT0038","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00126334-200404150-00005","article-title":"Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy","volume":"35","author":"Verhofstede","year":"2004","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2022020201070544400_CIT0039","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1097\/QAD.0000000000000723","article-title":"Levels of intracellular HIV-DNA in patients with suppressive antiretroviral therapy","volume":"29","author":"Cuzin","year":"2015","journal-title":"AIDS"},{"key":"2022020201070544400_CIT0040","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/QAD.0000000000001476","article-title":"Individualized antiretroviral therapeutic approaches: less can be more","volume":"31","author":"Katlama","year":"2017","journal-title":"AIDS"},{"key":"2022020201070544400_CIT0041","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/jac\/dkab002","article-title":"Deep sequencing analysis of M184V\/I mutation at the switch and at the time of virological failure of boosted protease inhibitor plus lamivudine or boosted protease inhibitor maintenance strategy (substudy of the ANRS-MOBIDIP trial)","volume":"76","author":"Delaugerre","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"2022020201070544400_CIT0042","article-title":"Virological efficacy and tolerability of dual therapy maintenance with dolutegravir plus lamivudine in heavily treatment experienced HIV-infected patients: four years data from DOLULAM study,","author":"Reynes"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiab413\/40431873\/jiab413.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/225\/3\/502\/42361102\/jiab413.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/225\/3\/502\/42361102\/jiab413.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T19:06:59Z","timestamp":1725649619000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/225\/3\/502\/6355381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,20]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,8,20]]},"published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiab413","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2,1]]},"published":{"date-parts":[[2021,8,20]]}}}