{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:49:08Z","timestamp":1777034948554,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"Supplement_5","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-009497-OPP1159351"],"award-info":[{"award-number":["INV-009497-OPP1159351"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is a lack of evident data to explain the true scenario of age-specific enteric fever in India. The current study aimed to evaluate the burden and disease pattern of enteric fever among infants in a tertiary care pediatric hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective laboratory-based surveillance was conducted from April 2018 to January 2020 at a children\u2019s hospital in North India, under the Surveillance for Enteric Fever in India study. The study included children &amp;lt;1 year of age in whom Salmonella serovar Typhi\/Salmonella serovar Paratyphi grew in cultures from blood or sterile body fluid. The key outcome measures included disease spectrum and clinical presentation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 10 737 blood cultures from infants, 26 were positive for S. Typhi or S. Paratyphi. The majority of cases occurred in infants aged 6\u201312 months, with the youngest being 1 month old. Fever with abdominal pain and diarrhea were the common symptoms, with 46% of infants requiring inpatient care. All of the isolates were susceptible to ceftriaxone. Third-generation cephalosporins were used as the first-line therapy for hospitalized infants. The average duration of fever was 8.6 days. The overall case-fatality rate among infants with enteric fever was 7.4%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Enteric fever is a major contributor to disease and death among children. Robust surveillance studies are required to understand the true disease burden.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab430","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:17:50Z","timestamp":1631099870000},"page":"S568-S572","source":"Crossref","is-referenced-by-count":1,"title":["Clinicoepidemiological Observations of Enteric Fever in Infants: Experiences From a Tertiary Care Pediatric Hospital in North India"],"prefix":"10.1093","volume":"224","author":[{"given":"Karnika","family":"Saigal","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, Chacha Nehru Bal Chikitsalaya, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, Chacha Nehru Bal Chikitsalaya, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diganta","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"2022030311114690400_CIT0001","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/cid\/ciy846","article-title":"Progress in typhoid fever epidemiology","volume":"68","author":"Crump","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2022030311114690400_CIT0002","doi-asserted-by":"crossref","first-page":"e93784","DOI":"10.1371\/journal.pone.0093784","article-title":"Case fatality rate and length of hospital stay among patients with typhoid intestinal perforation in developing countries: a systematic literature review","volume":"9","author":"Mogasale","year":"2014","journal-title":"PloS One"},{"key":"2022030311114690400_CIT0003","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1473-3099(18)30685-6","article-title":"The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017","volume":"19","author":"GBD 2017 Typhoid and Paratyphoid Collaborators","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"2022030311114690400_CIT0004","doi-asserted-by":"crossref","first-page":"020407","DOI":"10.7189\/jogh.05.020407","article-title":"Systematic review of the global epidemiology, clinical and laboratory profile of enteric fever","volume":"5","author":"Azmatullah","year":"2015","journal-title":"J Glob Health"},{"key":"2022030311114690400_CIT0005","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/cid\/cix229","article-title":"An appraisal of the clinical features of pediatric enteric fever: systematic review and meta-analysis of the age-stratified disease occurrence","volume":"64","author":"Britto","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2022030311114690400_CIT0006","first-page":"45","article-title":"Clinical profile of typhoid fever in children aged between 6 months to 18 years: a study in a tertiary care hospital, Chittagong, Bangladesh","volume":"17","author":"Zabeen","year":"2018","journal-title":"IOSR J Dent Med Sci"},{"key":"2022030311114690400_CIT0007","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12879-019-3917-3","article-title":"A cross-sectional study of enteric fever among febrile patients at Ambo hospital: prevalence, risk factors, comparison of Widal test and stool culture and antimicrobials susceptibility pattern of isolates","volume":"19","author":"Deksissa","year":"2019","journal-title":"BMC Infect Dis"},{"key":"2022030311114690400_CIT0008","doi-asserted-by":"crossref","first-page":"e0004616","DOI":"10.1371\/journal.pntd.0004616","article-title":"The burden of typhoid and paratyphoid in India: systematic review and meta-analysis","volume":"10","author":"John","year":"2016","journal-title":"PloS Negl Trop Dis"},{"key":"2022030311114690400_CIT0009","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1186\/s12889-018-5498-2","article-title":"Estimating the incidence of enteric fever in children in India: a multi-site, active fever surveillance of pediatric cohorts","volume":"18","author":"John","year":"2018","journal-title":"BMC Public Health"},{"key":"2022030311114690400_CIT0010","first-page":"729","article-title":"Meeting of the strategic advisory group of experts on immunization, October 2017\u2014conclusions and recommendations","volume":"92","author":"World Health Organization","year":"2017","journal-title":"Wkly Epidemiol Rec"},{"key":"2022030311114690400_CIT0011","volume-title":"Performance standards for antimicrobial susceptibility testing; twenty-fifth informational supplement. 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