{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:06:59Z","timestamp":1793074019600,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/igo\/"}],"funder":[{"DOI":"10.13039\/100011893","name":"PAHO","doi-asserted-by":"publisher","award":["NU50CK000494"],"award-info":[{"award-number":["NU50CK000494"]}],"id":[{"id":"10.13039\/100011893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hantavirus is known to be transmitted from rodents to humans. However, some reports from Argentina and Chile have claimed that the hantavirus strain Andes virus (ANDV) can cause human-to-human transmission of the disease. The aim of this systematic review was to assess the evidence for human-to-human transmission of hantavirus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We searched PubMed (inception to 28 February 2021), Cochrane Central, Embase, LILACS and SciELO (inception to 3 July 2020), and other sources. We included studies that assessed whether interpersonal contact with a person with laboratory-confirmed hantavirus infection led to human-to-human transmission. Two reviewers conducted screening, selection, data extraction, and risk of bias assessment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-two studies met the inclusion criteria. Meta-analysis was not possible due to heterogeneity. With the exception of 1 prospective cohort study of ANDV in Chile with serious risk of bias, evidence from comparative studies (strongest level of evidence available) does not support human-to-human transmission of hantavirus infection. Noncomparative studies with a critical risk of bias suggest that human-to-human transmission of ANDV may be possible.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The balance of the evidence does not support the claim of human-to-human transmission of ANDV. Well-designed cohort and case-control studies that control for co-exposure to rodents are needed to inform public health recommendations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab461","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T03:07:51Z","timestamp":1631243271000},"page":"1362-1371","source":"Crossref","is-referenced-by-count":74,"title":["Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review"],"prefix":"10.1093","volume":"226","author":[{"given":"Joao","family":"Toledo","sequence":"first","affiliation":[{"name":"Department of Health Emergencies, Pan American Health Organization , Washington, District of Columbia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-9195","authenticated-orcid":false,"given":"Michelle M","family":"Haby","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad de Sonora , Hermosillo, Sonora , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Reveiz","sequence":"additional","affiliation":[{"name":"Department of Evidence and Intelligence for Action in Health, Pan American Health Organization , Washington, District of Columbia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Sosa Leon","sequence":"additional","affiliation":[{"name":"Independent consultant , Hermosillo, Sonora , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Angerami","sequence":"additional","affiliation":[{"name":"Hospital Epidemiology Section, Hospital of Clinics, State University of Campinas , Campinas, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Aldighieri","sequence":"additional","affiliation":[{"name":"Hospital Epidemiology Section, Hospital of Clinics, State University of Campinas , Campinas, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"2022101708571267800_CIT0001","first-page":"421","article-title":"Outbreak of acute illness\u2014southwestern United States, 1993","volume":"42","author":"Centers for Disease Control and Prevention","year":"1993","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2022101708571267800_CIT0002","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.med.50.1.531","article-title":"Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome","volume":"50","author":"Peters","year":"1999","journal-title":"Annu Rev Med"},{"key":"2022101708571267800_CIT0003","author":"Centers for Disease Control and Prevention"},{"key":"2022101708571267800_CIT0004","author":"Pan American Health Organization"},{"key":"2022101708571267800_CIT0005","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/infdis\/173.6.1297","article-title":"Hantavirus pulmonary syndrome: the first 100 US cases","volume":"173","author":"Khan","year":"1996","journal-title":"J Infect Dis"},{"key":"2022101708571267800_CIT0006","first-page":"709","article-title":"Hantavirus pulmonary syndrome in Argentina. 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