{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:11:05Z","timestamp":1792681865499,"version":"4.5.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sao Paulo Research Foundation","award":["2012\/01278\u20130"],"award-info":[{"award-number":["2012\/01278\u20130"]}]},{"name":"Sao Paulo Research Foundation","award":["2012\/16800\u20133"],"award-info":[{"award-number":["2012\/16800\u20133"]}]},{"name":"Sao Paulo Research Foundation","award":["2012\/10403\u20132"],"award-info":[{"award-number":["2012\/10403\u20132"]}]},{"name":"Sao Paulo Research Foundation","award":["2018\/18469\u20139"],"award-info":[{"award-number":["2018\/18469\u20139"]}]},{"DOI":"10.13039\/100009326","name":"Cancer Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interplay between vaginal microbiome and human papillomavirus (HPV) remains unclear, partly due to heterogeneity of microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from 546 women enrolled in a cross-sectional study in 5 Brazil. We genotyped vaginal samples for HPV and sequenced V3\u2013V4 region of 16S rRNA gene for vaginal microbiome analysis. We used stepwise logistic regression to construct 2 linear scores to predict high-risk HPV (hrHPV) positivity: one based exclusively on presence of individual bacterial taxa (microbiome-based [MB] score) and the other exclusively on participants\u2019 sociodemographic, behavioral, and clinical (SBC) characteristics. MB score combined coefficients of 30 (of 116) species. SBC score retained 6 of 25 candidate variables. We constructed receiver operating characteristic curves for scores as hrHPV correlates and compared areas under the curve (AUC) and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, prevalence of hrHPV was 15.8%, and 26.2% had a Lactobacillus-depleted microbiome. AUCs were 0.8022 (95% CI, .7517\u2013.8527) for MB score and 0.7027 (95% CI, .6419\u2013.7636) for SBC score (P\u2005=\u2005.0163).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The proposed MB score is strongly correlated with hrHPV positivity\u2014exceeding the predictive value of behavioral variables\u2014suggesting its potential as an indicator of infection and possible value for clinical risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiab547","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T23:09:48Z","timestamp":1635203388000},"page":"1084-1097","source":"Crossref","is-referenced-by-count":23,"title":["Vaginal Microbiome Components as Correlates of Cervical Human Papillomavirus Infection"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-5620","authenticated-orcid":false,"given":"Julia","family":"Andrade Pessoa Morales","sequence":"first","affiliation":[{"name":"Department of Pathology, Botucatu Medical School, Sao Paulo State University , Botucatu, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Marconi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Botucatu Medical School, Sao Paulo State University , Botucatu, S\u00e3o Paulo , Brazil"},{"name":"Department of Basic Pathology, Federal University of Paran\u00e1 , Curitiba, Paran\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-0370","authenticated-orcid":false,"given":"Mariam","family":"El-Zein","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0851-2233","authenticated-orcid":false,"given":"Jacques","family":"Ravel","sequence":"additional","affiliation":[{"name":"Institute of Genomic Science, University of Maryland School of Medicine , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Victor","family":"da Silva Pinto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Botucatu Medical School, Sao Paulo State University , Botucatu, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Botucatu Medical School, Sao Paulo State University , Botucatu, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moises Diogode","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Federal University of Paraiba , Jo\u00e3o Pessoa, Paraiba , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newton Sergio","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Basic Pathology, Federal University of Paran\u00e1 , Curitiba, Paran\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane Ribeiro Figueiredo","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Federal University of Goias , Goiania, Goias , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Maria Garcia","family":"de Lima Parada","sequence":"additional","affiliation":[{"name":"Department of Nursing, Botucatu Medical School, Sao Paulo State University , Botucatu, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Helena Morais","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, State University of Para , Belem, Par\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa L","family":"Villa","sequence":"additional","affiliation":[{"name":"Center for Translational Investigation in Oncology, Cancer Institute of S\u00e3o Paulo State, Medical School, S\u00e3o Paulo State University , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Guimar\u00e3es","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology, Botucatu Medical School, Sao Paulo State University , Botucatu, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"2022092122004775400_CIT0001","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41591-019-0450-2","article-title":"The vaginal microbiome and preterm birth.","volume":"25","author":"Fettweis","year":"2019","journal-title":"Nat Med"},{"key":"2022092122004775400_CIT0002","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/s41591-019-0663-4","article-title":"Author correction: metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.","volume":"25","author":"Thomas","year":"2019","journal-title":"Nat Med"},{"key":"2022092122004775400_CIT0003","doi-asserted-by":"crossref","first-page":"e102467","DOI":"10.1371\/journal.pone.0102467","article-title":"Free glycogen in vaginal fluids is associated with Lactobacillus colonization and low vaginal pH.","volume":"9","author":"Mirmonsef","year":"2014","journal-title":"PLoS One"},{"key":"2022092122004775400_CIT0004","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1073\/pnas.1002611107","article-title":"Vaginal microbiome of reproductive-age women.","volume":"108","author":"Ravel","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022092122004775400_CIT0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.annepidem.2011.11.005","article-title":"Bacterial vaginosis, gonorrhea, and chlamydial infection among women attending a sexually transmitted disease clinic: a longitudinal analysis of possible causal links.","volume":"22","author":"Gallo","year":"2012","journal-title":"Ann Epidemiol"},{"key":"2022092122004775400_CIT0006","doi-asserted-by":"crossref","first-page":"319460","DOI":"10.1155\/2011\/319460","article-title":"Bacterial vaginosis and the natural history of human papillomavirus.","volume":"2011","author":"King","year":"2011","journal-title":"Infect Dis Obstet Gynecol"},{"key":"2022092122004775400_CIT0007","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1086\/427777","article-title":"Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women.","volume":"191","author":"Watts","year":"2005","journal-title":"J Infect Dis"},{"key":"2022092122004775400_CIT0008","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1158\/1055-9965.EPI-10-0394","article-title":"The role of sexual behavior and human papillomavirus persistence in predicting repeated infections with new human papillomavirus types.","volume":"19","author":"Moscicki","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2022092122004775400_CIT0009","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods.","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int J Cancer"},{"key":"2022092122004775400_CIT0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/cncr.22947","article-title":"Candida and dysbacteriosis: a cytologic, population-based study of 100,605 asymptomatic women concerning cervical carcinogenesis.","volume":"111","author":"Engberts","year":"2007","journal-title":"Cancer"},{"key":"2022092122004775400_CIT0011","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijgo.2011.03.011","article-title":"Bacterial vaginosis as a risk factor for high-grade cervical lesions and cancer in HIV-seropositive women.","volume":"114","author":"Denslow","year":"2011","journal-title":"Int J Gynaecol Obstet"},{"key":"2022092122004775400_CIT0012","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1038\/s41598-017-09842-6","article-title":"Characterization of cervico-vaginal microbiota in women developing persistent high-risk human papillomavirus infection.","volume":"7","author":"Di Paola","year":"2017","journal-title":"Sci Rep"},{"key":"2022092122004775400_CIT0013","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/infdis\/jiw374","article-title":"The cervicovaginal microbiota and its associations with human papillomavirus detection in HIV-infected and HIV-uninfected women.","volume":"214","author":"Reimers","year":"2016","journal-title":"J Infect Dis"},{"key":"2022092122004775400_CIT0014","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/infdis\/jiu330","article-title":"Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection.","volume":"210","author":"Brotman","year":"2014","journal-title":"J Infect Dis"},{"key":"2022092122004775400_CIT0015","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/OLQ.0000000000001204","article-title":"Characterization of the vaginal microbiome in women of reproductive age from 5 regions in Brazil.","volume":"47","author":"Marconi","year":"2020","journal-title":"Sex Transm Dis"},{"key":"2022092122004775400_CIT0016","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/jcm.29.2.297-301.1991","article-title":"Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation.","volume":"29","author":"Nugent","year":"1991","journal-title":"J Clin Microbiol"},{"key":"2022092122004775400_CIT0017","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2049-2618-2-6","article-title":"An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform.","volume":"2","author":"Fadrosh","year":"2014","journal-title":"Microbiome"},{"key":"2022092122004775400_CIT0018","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies.","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"2022092122004775400_CIT0019","doi-asserted-by":"crossref","first-page":"10.7.1","DOI":"10.1002\/0471250953.bi1007s36","article-title":"Using QIIME to analyze 16S rRNA gene sequences from microbial communities.","volume":"36","author":"Kuczynski","year":"2011","journal-title":"Curr Protoc Bioinformatics"},{"key":"2022092122004775400_CIT0020","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection.","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"2022092122004775400_CIT0021","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea.","volume":"6","author":"McDonald","year":"2012","journal-title":"ISME J"},{"key":"2022092122004775400_CIT0022","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/OLQ.0000000000001204","article-title":"Characterization of the vaginal microbiome in women of reproductive age from 5 regions in Brazil.","volume":"47","author":"Marconi","year":"2020","journal-title":"Sex Transm Dis"},{"key":"2022092122004775400_CIT0023","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/1471-0528.15854","article-title":"The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis.","volume":"127","author":"Norenhag","year":"2020","journal-title":"BJOG"},{"key":"2022092122004775400_CIT0024","doi-asserted-by":"crossref","first-page":"132ra52","DOI":"10.1126\/scitranslmed.3003605","article-title":"Temporal dynamics of the human vaginal microbiota.","volume":"4","author":"Gajer","year":"2012","journal-title":"Sci Transl Med"},{"key":"2022092122004775400_CIT0025","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1590\/1516-3180.2014.9182710","article-title":"Bacterial vaginosis in pregnant adolescents: proinflammatory cytokine and bacterial sialidase profile. Cross-sectional study.","volume":"133","author":"Ferreira","year":"2015","journal-title":"Sao Paulo Med J"},{"key":"2022092122004775400_CIT0026","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/LGT.0000000000000003","article-title":"Cervicovaginal levels of proinflammatory cytokines are increased during chlamydial infection in bacterial vaginosis but not in lactobacilli-dominated flora.","volume":"18","author":"Marconi","year":"2014","journal-title":"J Low Genit Tract Dis"},{"key":"2022092122004775400_CIT0027","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/jcm.30.2.465-472.1992","article-title":"Development of a polymerase chain reaction-based diagnosis of Trichomonas vaginalis.","volume":"30","author":"Riley","year":"1992","journal-title":"J Clin Microbiol"},{"key":"2022092122004775400_CIT0028","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.anaerobe.2014.12.003","article-title":"Mageeibacillus indolicus gen. nov., sp. nov.: a novel bacterium isolated from the female genital tract.","volume":"32","author":"Austin","year":"2015","journal-title":"Anaerobe"},{"key":"2022092122004775400_CIT0029","doi-asserted-by":"crossref","first-page":"14095","DOI":"10.1038\/s41598-019-50410-x","article-title":"Diversity of vaginal microbiome and metabolome during genital infections.","volume":"9","author":"Ceccarani","year":"2019","journal-title":"Sci Rep"},{"key":"2022092122004775400_CIT0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1017\/S0950268815000965","article-title":"Prevalent high-risk HPV infection and vaginal microbiota in Nigerian women.","volume":"144","author":"Dareng","year":"2016","journal-title":"Epidemiol Infect"},{"key":"2022092122004775400_CIT0031","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/infdis\/jiz325","article-title":"Associations of cervicovaginal lactobacilli with high-risk human papillomavirus infection, cervical intraepithelial neoplasia, and cancer: a systematic review and meta-analysis.","volume":"220","author":"Wang","year":"2019","journal-title":"J Infect Dis"},{"key":"2022092122004775400_CIT0032","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ajog.2018.12.011","article-title":"Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis.","volume":"221","author":"Brusselaers","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"2022092122004775400_CIT0033","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.31342","article-title":"Cervicovaginal microbiota composition correlates with the acquisition of high-risk human papillomavirus types.","volume":"143","author":"Huang","year":"2018","journal-title":"Int J Cancer"},{"key":"2022092122004775400_CIT0034","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pvr.2019.04.006","article-title":"The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection.","volume":"7","author":"Onywera","year":"2019","journal-title":"Papillomavirus Res"},{"key":"2022092122004775400_CIT0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijgo.2015.05.016","article-title":"Prevalence of and risk factors for bacterial vaginosis among women of reproductive age attending cervical screening in southeastern Brazil.","volume":"131","author":"Marconi","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"2022092122004775400_CIT0036","doi-asserted-by":"crossref","first-page":"e0229154","DOI":"10.1371\/journal.pone.0229154","article-title":"Prevalence of human papillomavirus (HPV) in Brazil: a systematic review and meta-analysis.","volume":"15","author":"Colpani","year":"2020","journal-title":"PLoS One"},{"key":"2022092122004775400_CIT0037","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12879-016-1446-x","article-title":"Reproductive and genital health and risk of cervical human papillomavirus infection: results from the Ludwig-McGill cohort study.","volume":"16","author":"Shaw","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2022092122004775400_CIT0038","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00007435-200211000-00018","article-title":"Do condoms prevent genital HPV infection, external genital warts, or cervical neoplasia? A meta-analysis.","volume":"29","author":"Manhart","year":"2002","journal-title":"Sex Transm Dis"},{"key":"2022092122004775400_CIT0039","first-page":"759","article-title":"Understanding the epidemiology of genital infection with oncogenic and nononcogenic human papillomaviruses: a promising lead for primary prevention of cervical cancer.","volume":"6","author":"Franco","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2022092122004775400_CIT0040","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/infdis\/174.4.679","article-title":"Sexual behavior and partner characteristics are the predominant risk factors for genital human papillomavirus infection in young women.","volume":"174","author":"Burk","year":"1996","journal-title":"J Infect Dis"},{"key":"2022092122004775400_CIT0041","doi-asserted-by":"crossref","first-page":"e1008376","DOI":"10.1371\/journal.ppat.1008376","article-title":"Cervicovaginal microbiome and natural history of HPVin a longitudinal study.","volume":"16","author":"Usyk","year":"2020","journal-title":"PLoS Pathog"},{"key":"2022092122004775400_CIT0042","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fcimb.2020.00286","article-title":"The alterations of vaginal microbiome in HPV16 infection as identified by shotgun metagenomic sequencing.","volume":"10","author":"Yang","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"2022092122004775400_CIT0043","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/infdis\/jiz342","article-title":"An updated conceptual model on the pathogenesis of bacterial vaginosis.","volume":"220","author":"Muzny","year":"2019","journal-title":"J Infect Dis"},{"key":"2022092122004775400_CIT0044","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1186\/s12879-019-4279-6","article-title":"Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women.","volume":"19","author":"Chen","year":"2019","journal-title":"BMC Infect Dis"},{"key":"2022092122004775400_CIT0045","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41467-020-15856-y","article-title":"The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions.","volume":"11","author":"Mitra","year":"2020","journal-title":"Nat Commun"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiab547\/42090371\/jiab547.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/226\/6\/1084\/45966827\/jiab547.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/226\/6\/1084\/45966827\/jiab547.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T18:05:00Z","timestamp":1663783500000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/226\/6\/1084\/6413719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,10,28]]},"published-print":{"date-parts":[[2022,9,21]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiab547","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,15]]},"published":{"date-parts":[[2021,10,28]]}}}