{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:24:34Z","timestamp":1764350674477},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Elimination of poliovirus in Pakistan and Afghanistan is challenged by notions against the role of oral poliovirus vaccine (OPV) in eradicating contemporary wild poliovirus (WPV) strains.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 1055 WPV type 1 (WPV1) strains isolated between 2013 and 2018 were categorized into 68 antigenic groups and tested for neutralization by OPV-derived antibodies. Molecular docking was conducted to determine neutralization efficiency of antibodies against WPV. The clinical significance of WPV1 variants was assessed to ascertain their role in patient outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that 88% of WPV1 strains isolated from paralytic children belonged to a single antigenic lineage identical to the WPV1 strain detected in 1993. WPV1 antigenic variants were effectively neutralized by OPV-derived antibodies, with geometric mean titers comparable to the neutralization titers found for 3 strains in OPV (OPV1\u20133, 7.96\u20139.149 [95% confidence interval, 6.864\u201310.171]; WPV1 strains, 7.542\u20138.786 [6.493\u20139.869]). Docking examination underscored a strong antigen-antibody interaction despite variations within the viral protein 1 epitopes. There was no significant association (P =\u00a0.78) with clinical prognosis among patients infected with antigenically diverse WPV1 strains and patient outcomes, including death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings substantiate the robustness of OPV for neutralizing the contemporary WPV1 strains endemic in Pakistan and Afghanistan. Vaccination coverage must be augmented to achieve early eradication.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab555","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T12:06:46Z","timestamp":1635682006000},"page":"843-851","source":"Crossref","is-referenced-by-count":3,"title":["Conserved Antigenic Structure of Contemporary Wild Poliovirus Type 1 Strains Endemic in Pakistan"],"prefix":"10.1093","volume":"226","author":[{"given":"Muhammad Masroor","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamir","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayab","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salmaan","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahzad","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Qaiser","family":"Fatmi","sequence":"additional","affiliation":[{"name":"COMSATS University , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehar","family":"Angez","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ribqa","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam","family":"Mujtaba","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Suleman","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneela","family":"Yousaf","sequence":"additional","affiliation":[{"name":"COMSATS University , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Sohail Zahoor","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Salman","sequence":"additional","affiliation":[{"name":"Department of Virology, National Institute of Health , Chak Shahzad, Islamabad , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"2022091319160343700_CIT0001","author":"World Health Organization, Weekly Country Updates on Polio.","year":"2015"},{"key":"2022091319160343700_CIT0002","doi-asserted-by":"crossref","first-page":"e107697","DOI":"10.1371\/journal.pone.0107697","article-title":"Molecular characterization and phylogenetic relationship of wild type 1 poliovirus strains circulating across Pakistan and Afghanistan bordering areas during 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