{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:29:31Z","timestamp":1789817371502,"version":"4.0.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Respiratory syncytial virus (RSV) causes a substantial burden in older adults. Viral load in RSV-infected adults is generally lower compared to young children, which could result in suboptimal sensitivity of RSV diagnostics. Although the Xpert\u00ae Xpress Flu\/RSV assay has been used in routine clinical care, its sensitivity to diagnose RSV infection in older adults is largely unknown. We aimed to compare the performance of the Xpert\u00ae Xpress Flu\/RSV assay with real-time reverse-transcription polymerase chain reaction (RT-PCR) in home-dwelling older adults (\u226560 years of age).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Nasopharyngeal swabs were tested with Xpert\u00ae Xpress Flu\/RSV and compared to RSV RT-PCR in older adults with acute respiratory tract infections with different levels of disease severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We studied 758 respiratory samples from 561 older adults from 2 consecutive RSV seasons. Thirty-five (4.6%) samples tested positive for RSV by at least 1 of the assays, of which 2 samples were negative by Xpert\u00ae Xpress Flu\/RSV and 3 samples by real-time RT-PCR. The positive percentage agreement (PPA) was 90.9% (95% confidence interval [CI], 76.4%\u201396.8%) and negative percentage agreement was 99.7% (95% CI, 99.0%\u201399.9%). Viral loads were low (\u2264103 copies\/mL or cycle threshold value \u226534) in all cases with discordant results for the 2 assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The PPA of Xpert\u00ae Xpress Flu\/RSV compared to routine RT-PCR is high for RSV detection in home-dwelling older adults. The assay is fast and easy to use at the point of care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT03621930.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiab600","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T20:09:45Z","timestamp":1640376585000},"page":"S63-S70","source":"Crossref","is-referenced-by-count":23,"title":["Performance Assessment of a Rapid Molecular Respiratory Syncytial Virus Point-of-Care Test: A Prospective Community Study in Older Adults"],"prefix":"10.1093","volume":"226","author":[{"given":"Roy P","family":"Zuurbier","sequence":"first","affiliation":[{"name":"Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children\u2019s Hospital\/University Medical Centre Utrecht , Utrecht , The Netherlands"},{"name":"Spaarne Gasthuis Academy , Hoofddorp and Haarlem , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-4113","authenticated-orcid":false,"given":"Koos","family":"Korsten","sequence":"additional","affiliation":[{"name":"Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children\u2019s Hospital\/University Medical Centre Utrecht , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo J M","family":"Verheij","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Primary Care Health Sciences, University of Oxford , Oxford , United 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G","family":"Wildenbeest","sequence":"additional","affiliation":[{"name":"Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children\u2019s Hospital\/University Medical Centre Utrecht , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"REspiratory Syncytial Virus Consortium in EUrope (RESCEU) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Zuurbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koos","family":"Korsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Verheij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"van 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