{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:10:36Z","timestamp":1780805436087,"version":"3.54.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["643558"],"award-info":[{"award-number":["643558"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic immune activation is the key pathogenetic event of Mycobacterium tuberculosis-human immunodeficiency virus (HIV) coinfection. We assessed the therapeutic value of phosphatidylserine-liposome (PS-L) in an in vitro model of M. tuberculosis-HIV coinfection. PS-L reduced nuclear factor-\u03baB activation and the downstream production of tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2), and IL-6 in bacille Calmette-Gu\u00e9rin-infected macrophages and of TNF-\u03b1 and IL-1\u03b2 in M. tuberculosis-infected and M. tuberculosis-HIV\u2013coinfected macrophages. Importantly, a significant reduction of intracellular M. tuberculosis viability and HIV replication were also observed. These results support the further exploitation of PS-L as host-directed therapy for M. tuberculosis-HIV coinfection.<\/jats:p>","DOI":"10.1093\/infdis\/jiab602","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T20:12:50Z","timestamp":1639426370000},"page":"1675-1679","source":"Crossref","is-referenced-by-count":10,"title":["Phosphatidylserine Liposomes Reduce Inflammatory Response, Mycobacterial Viability, and HIV Replication in Coinfected Human Macrophages"],"prefix":"10.1093","volume":"225","author":[{"given":"Noemi","family":"Poerio","sequence":"first","affiliation":[{"name":"Department of Biology, University of Rome Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia R","family":"Caccamo","sequence":"additional","affiliation":[{"name":"Central Laboratory of Advanced Diagnosis and Biomedical Research, Palermo, Italy"},{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco P","family":"La Manna","sequence":"additional","affiliation":[{"name":"Central Laboratory of Advanced Diagnosis and Biomedical Research, Palermo, Italy"},{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Olimpieri","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Henrici","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome Tor Vergata, Rome, Italy"},{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco 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