{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:16Z","timestamp":1787008996410,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["CDC-RFA-IP16\u2013004"],"award-info":[{"award-number":["CDC-RFA-IP16\u2013004"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Studies have shown egg-adaptive mutations in influenza vaccine strains that might have impaired protection against circulating A(H3N2) influenza viruses during the 2016\u20132017 and 2017\u20132018 seasons. We used the test-negative design and multivariable models to assess vaccine effectiveness against influenza-associated hospitalization and emergency department visits among children\u2005(&amp;lt;18 years old) during the 2016\u20132017 and 2017\u20132018 seasons. Effectiveness was 71% (95% confidence interval, 59%\u201379%), 46% (35%\u201355%), and 45% (33%\u201355%) against A(H1N1)pdm09, A(H3N2), and B viruses respectively, across both seasons. During high-severity seasons with concerns for vaccine mismatch, vaccination offered substantial protection against severe influenza outcomes requiring hospitalization or emergency department visits among children.<\/jats:p>","DOI":"10.1093\/infdis\/jiab624","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T15:10:28Z","timestamp":1640099428000},"page":"91-96","source":"Crossref","is-referenced-by-count":12,"title":["Vaccine Effectiveness Against Influenza Hospitalization and Emergency Department Visits in 2 A(H3N2) Dominant Influenza Seasons Among Children &amp;lt;18 Years Old\u2014New Vaccine Surveillance Network 2016\u20132017 and 2017\u20132018"],"prefix":"10.1093","volume":"226","author":[{"given":"Sara S","family":"Kim","sequence":"first","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian G","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-6657","authenticated-orcid":false,"given":"Rangaraj","family":"Selvarangan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Infectious Diseases Division, Children\u2019s Mercy\u2013Kansas City and University of Missouri , Kansas City, Kansas City, Missouri ,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, Children\u2019s Mercy\u2013Kansas City and University of Missouri\u2013Kansas City , Kansas City, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Infectious Diseases Division, Children\u2019s Mercy\u2013Kansas City and University of Missouri , Kansas City, Kansas City, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A","family":"Staat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P","family":"Schlaudecker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A","family":"Weinberg","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry , Rochester, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"Szilagyi","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry , Rochester, New York ,","place":["USA"]},{"name":"University of California at Los Angeles , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A","family":"Boom","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Texas Children\u2019s Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila C","family":"Sahni","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Texas Children\u2019s Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A","family":"Englund","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen J","family":"Klein","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance E","family":"Ogokeh","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela P","family":"Campbell","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia 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