{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:29:44Z","timestamp":1788953384350,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD079695"],"award-info":[{"award-number":["R01 HD079695"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD079695-S"],"award-info":[{"award-number":["R01 HD079695-S"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007813","name":"University of Washington Center for AIDS Research","doi-asserted-by":"publisher","award":["P30 AI027757"],"award-info":[{"award-number":["P30 AI027757"]}],"id":[{"id":"10.13039\/100007813","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Washington Global Center for Integrated Health of Women, Adolescents, and Children"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cytomegalovirus (CMV) viremia is associated with mortality in severely ill immunocompetent adults and hospitalized children with HIV (CWH). We measured CMV viremia in HIV-exposed and -unexposed Kenyan children aged 1\u201359 months discharged from hospital and determined its relationship with postdischarge mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>CMV DNA levels were measured in plasma from 1024 children (97 of which were HIV exposed uninfected [HEU], and 15 CWH). Poisson and Cox proportional hazards regression models were used to identify correlates of CMV viremia \u2265 1000 IU\/mL &amp;#x2028;and estimate associations with 6-month mortality, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CMV viremia was detected in 31% of children, with levels \u2265 1000 IU\/mL in 5.8%. HIV infection, age &amp;lt; 2 years, breastfeeding, and midupper arm circumference &amp;lt; 12.5 cm were associated with CMV viremia \u2265 1000 IU\/mL. Among HEU children, CMV \u2265 1000 IU\/mL (hazard ratio [HR] = 32.0; 95% confidence interval [CI], 2.9\u2013354.0; P = .005) and each 1-log increase in CMV viral load (HR = 5.04; 95% CI, 1.7\u201314.6; P = .003) were associated with increased risk of mortality. CMV viremia was not significantly associated with mortality in HIV-unexposed children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CMV levels at hospital postdischarge predict increased risk of 6-month mortality in Kenyan HEU children. CMV suppression may be a novel target to reduce mortality in HEU children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>NCT02414399.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac047","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:07:26Z","timestamp":1644581246000},"page":"1519-1527","source":"Crossref","is-referenced-by-count":12,"title":["Cytomegalovirus Viremia Predicts Postdischarge Mortality in Kenyan HIV-Exposed Uninfected Children"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-9131","authenticated-orcid":false,"given":"Patricia B","family":"Pavlinac","sequence":"first","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington , USA"},{"name":"Department of Epidemiology, University of Washington , Seattle, 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Washington , Seattle, Washington , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E","family":"Atlas","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mame Mareme","family":"Diakhate","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Brander","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liru","family":"Meshak","sequence":"additional","affiliation":[{"name":"Homa Bay Teaching and Referral Hospital , Homa Bay , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Bogonko","sequence":"additional","affiliation":[{"name":"Kisii Teaching and Referral Hospital , Kisii , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirkby D","family":"Tickell","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington , USA"},{"name":"Childhood Acute Illness and Nutrition Network , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine J","family":"McGrath","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington , USA"},{"name":"Childhood Acute Illness and Nutrition Network , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irine M","family":"Machuara","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick O","family":"Ounga","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Berkley","sequence":"additional","affiliation":[{"name":"Childhood Acute Illness and Nutrition Network , Nairobi , Kenya"},{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme , Kilifi , Kenya"},{"name":"Center for Tropical Medicine and Global Health, University of Oxford , Oxford , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbra A","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington , USA"},{"name":"Department of Biostatistics, University of Washington , Seattle, Washington , 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