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Through mixed-model analyses of a dataset of Ugandan preschool children, we explore how current coinfection and prior infection with either Schistosoma mansoni or Plasmodium species alter subsequent Plasmodium intensity, Plasmodium risk, and S mansoni risk. Coinfection and prior infections with S mansoni were associated with reduced Plasmodium intensity, moderated by prior Plasmodium infections, wealth, and host age. Future work should assess whether these interactions impact host health and parasite control efficacy in this vulnerable age group.<\/jats:p>","DOI":"10.1093\/infdis\/jiac072","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T20:10:12Z","timestamp":1646251812000},"page":"2181-2186","source":"Crossref","is-referenced-by-count":7,"title":["Infection History and Current Coinfection With <i>Schistosoma mansoni<\/i> Decreases <i>Plasmodium<\/i> Species Intensities in Preschool Children in Uganda"],"prefix":"10.1093","volume":"225","author":[{"given":"Daniel","family":"McDowell","sequence":"first","affiliation":[{"name":"School of Biosciences, Cardiff University , Cardiff , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hurt","sequence":"additional","affiliation":[{"name":"School of Medicine, Cardiff University , Cardiff , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcis B","family":"Kabatereine","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-3420","authenticated-orcid":false,"given":"John Russell","family":"Stothard","sequence":"additional","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine , Liverpool , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Lello","sequence":"additional","affiliation":[{"name":"School of Biosciences, Cardiff University , Cardiff , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"2022061517104797200_CIT0001","doi-asserted-by":"crossref","DOI":"10.30875\/60123dd4-en","volume-title":"World Malaria Report 2020: 20 Years of Global Progress and 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