{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:41:50Z","timestamp":1771026110840,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2021-1-I2M-038"],"award-info":[{"award-number":["2021-1-I2M-038"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2019-I2M-5-042"],"award-info":[{"award-number":["2019-I2M-5-042"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672050"],"award-info":[{"award-number":["81672050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108023"],"award-info":[{"award-number":["81420108023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332021092"],"award-info":[{"award-number":["3332021092"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Antigens of migrating schistosomula are promising candidates as schistosomiasis vaccine targets, since immune attack on hepatic schistosomula would interrupt the parasites life cycle and reduce egg burden on the host.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, we report a collection of Schistosoma japonicum schistosomula proteins (SjScPs) that are highly expressed in hepatic schistosomula. The expression characteristics, antigenicity and immune protection of these proteins were studied by western blot, ELISA, immunofluorescence and challenge assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that several of these SjScPs were highly antigenic and could effectively stimulate humoral immune responses in both human and other mammalian hosts. In particular, SjScP25, SjScP37, SjScP41, SjScP80, and SjScP88 showed high potential as biomarkers for schistosomiasis immunodiagnosis. Furthermore, we demonstrated that immunization with several of the recombinant SjScPs were able to protect mice from S japonicum challenge infection, with SjScP25 generating the most protective results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our work represents a group of novel schistosome immunogens, which may be promising schistosomiasis japonica diagnosis and vaccine candidates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac077","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T12:07:55Z","timestamp":1646136475000},"page":"1991-2001","source":"Crossref","is-referenced-by-count":9,"title":["Novel Hepatic Schistosomula Antigens as Promising Targets for Immunodiagnosis and Immunoprotection of <i>Schistosomiasis japonica<\/i>"],"prefix":"10.1093","volume":"225","author":[{"given":"Nan","family":"Hou","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyu","family":"Piao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University , Shenyang , China"},{"name":"The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences , Shenyang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Cai","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Laboratory, Infectious Diseases Program, QIMR Berghofer Medical Research Institute , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute for Protein Science and Phage Research, the First Affiliated Hospital of Xi\u2019an Jiaotong University , Shanxi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P","family":"McManus","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Laboratory, Infectious Diseases Program, QIMR Berghofer Medical Research Institute , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qijun","family":"Chen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"},{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University , Shenyang , China"},{"name":"The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences , Shenyang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"2022060114581456800_CIT0001","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk.","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"2022060114581456800_CIT0002","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis.","volume":"4","author":"McManus","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2022060114581456800_CIT0003","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1080\/21645515.2015.1059981","article-title":"Still hope for schistosomiasis 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