{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:31:42Z","timestamp":1790721102935,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T00:00:00Z","timestamp":1646524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1AI104681"],"award-info":[{"award-number":["UM1AI104681"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antibiotic-associated diarrhea (AAD) is a common side effect of antibiotics. We examined the gastrointestinal microbiota in children treated with \u03b2-lactams for community-acquired pneumonia. Data were from 66 children (n = 198 samples), aged 6\u201371 months, enrolled in the SCOUT-CAP trial (NCT02891915). AAD was defined as \u22651 day of diarrhea. Stool samples were collected on study days 1, 6\u201310, and 19\u201325. Samples were analyzed using 16S ribosomal RNA gene sequencing to identify associations between patient characteristics, microbiota characteristics, and AAD (yes\/no). Nineteen (29%) children developed AAD. Microbiota compositional profiles differed between AAD groups (permutational multivariate analysis of variance, P &amp;lt; .03) and across visits (P &amp;lt; .001). Children with higher baseline relative abundances of 2 Bacteroides species were less likely to experience AAD. Higher baseline abundance of Lachnospiraceae and amino acid biosynthesis pathways were associated with AAD. Children in the AAD group experienced prolonged dysbiosis (P &amp;lt; .05). Specific gastrointestinal microbiota profiles are associated with AAD in children.<\/jats:p>","DOI":"10.1093\/infdis\/jiac082","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T23:13:10Z","timestamp":1646262790000},"page":"1109-1119","source":"Crossref","is-referenced-by-count":18,"title":["Gastrointestinal Microbiome Disruption and Antibiotic-Associated Diarrhea in Children Receiving Antibiotic Therapy for Community-Acquired Pneumonia"],"prefix":"10.1093","volume":"226","author":[{"given":"Jiye","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health , New Haven, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yale School of Public Health , New Haven, Connecticut , USA"},{"name":"Department of Molecular Biophysics and Biochemistry, W. M. Keck Foundation Biotechnology Resource Laboratory, Yale School of Medicine , New Haven, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health , New Haven, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine and the Monroe Carell Jr Children\u2019s Hospital at Vanderbilt , Nashville, Tennessee , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarence Buddy","family":"Creech","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine and the Monroe Carell Jr Children\u2019s Hospital at Vanderbilt , Nashville, Tennessee , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Evans","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Milken Institute School of Public Health, George Washington University , Washington, District of Columbia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel B","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Duke Human Vaccine Institute, Duke University School of Medicine , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy M","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Pittsburgh School of Medicine and the UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Gerber","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G","family":"Newland","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis School of Medicine , St Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E","family":"Hofto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham School of Medicine , Birmingham, Alabama , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Allen","family":"Staat","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center; Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance G","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Medicine and Duke Clinical Research Institute, Duke University School of Medicine , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Charles","family":"Huskins","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science and Department of Pediatric and Adolescent Medicine , Mayo Clinic, Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda M","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Microbial 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