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Children under 5 years old are those most vulnerable to CM, and they consequently have the highest risk of malaria-related death. Parasite-associated factors leading to CM are not yet fully elucidated. We therefore sought to characterize the gene expression profile associated with CM, using RNA sequencing data from 15 CM and 15 uncomplicated malaria isolates from Benin. Cerebral malaria parasites displayed reduced circulation times, possibly related to higher cytoadherence capacity. Consistent with the latter, we detected increased var genes abundance in CM isolates. Differential expression analyses showed that distinct transcriptome profiles are signatures of malaria severity. Genes involved in adhesion, excluding variant surface antigens, were dysregulated, supporting the idea of increased cytoadhesion capacity of CM parasites. Finally, we found dysregulated expression of genes in the entry into host pathway that may reflect greater erythrocyte invasion capacity of CM parasites.<\/jats:p>","DOI":"10.1093\/infdis\/jiac086","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T15:10:31Z","timestamp":1646320231000},"page":"2187-2196","source":"Crossref","is-referenced-by-count":27,"title":["Transcriptome Analysis of\n                    <i>Plasmodium falciparum<\/i>\n                    Isolates From Benin Reveals Specific Gene Expression Associated With Cerebral Malaria"],"prefix":"10.1093","volume":"225","author":[{"given":"E","family":"Guillochon","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, MERIT, IRD , Paris , France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1133, CNRS UMR 8251 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fraering","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, MERIT, IRD , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Joste","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, MERIT, IRD , Paris , France"},{"name":"Parasitology Laboratory, H\u00f4pital Bichat - Claude-Bernard, APHP , Paris , France"},{"name":"French Malaria Reference Center, H\u00f4pital Bichat, APHP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kamaliddin","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, The University of Calgary , Calgary, Alberta , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Vianou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, MERIT, IRD , Paris , France"},{"name":"Institut de Recherche Clinique du B\u00e9nin , Cotonou , B\u00e9nin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Houz\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, MERIT, IRD , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L G","family":"Baudrin","sequence":"additional","affiliation":[{"name":"Institut Curie Genomics of Excellence Platform, PSL Research University, Research Center, Institut Curie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Faucher","sequence":"additional","affiliation":[{"name":"INSERM, Univ. 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