{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:15Z","timestamp":1787008995860,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG SPP1937"],"award-info":[{"award-number":["DFG SPP1937"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TR57"],"award-info":[{"award-number":["SFB TR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Liver Foundation","award":["S163\/10103\/2014-BN"],"award-info":[{"award-number":["S163\/10103\/2014-BN"]}]},{"DOI":"10.13039\/501100021372","name":"Hector Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021372","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008131","name":"University of Bonn","doi-asserted-by":"publisher","award":["2020-1A-08"],"award-info":[{"award-number":["2020-1A-08"]}],"id":[{"id":"10.13039\/501100008131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008131","name":"University of Bonn","doi-asserted-by":"publisher","award":["2019-1A-09"],"award-info":[{"award-number":["2019-1A-09"]}],"id":[{"id":"10.13039\/501100008131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we observed that several parameters were significantly reduced in HIV+ NK cells, indicating a mitochondrial defect. Accordingly, we found HIV+ CD56bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with interferon gamma (IFN-\u03b3) production of NK cells. Finally, we demonstrated that stimulation of HIV+ NK cells with MitoTEMPO, a mitochondria-targeting antioxidant, significantly improved IFN-\u03b3 production. We identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.<\/jats:p>","DOI":"10.1093\/infdis\/jiac103","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T16:09:50Z","timestamp":1647619790000},"page":"901-906","source":"Crossref","is-referenced-by-count":11,"title":["Mitochondrial Dysfunction Contributes to Impaired Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus\u2013Infected Individuals Under Effective Antiretroviral Therapy"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-9741","authenticated-orcid":false,"given":"Michael","family":"ToVinh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"},{"name":"German Center for Infection Research, Thematical Translational Units HIV , Cologne\/Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"H\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"},{"name":"German Center for Infection Research, Thematical Translational Units HIV , Cologne\/Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiyana","family":"Dobrikova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gotter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"},{"name":"German Center for Infection Research, Thematical Translational Units HIV , Cologne\/Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"},{"name":"German Center for Infection Research, Thematical Translational Units HIV , Cologne\/Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Raabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Finnemann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-2915","authenticated-orcid":false,"given":"Jenny","family":"Bischoff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon J","family":"Rieke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"M\u00f6hl","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases, Image and Data Analysis Facility , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoureh","family":"Aghabeig","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases, Image and Data Analysis Facility , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolynne","family":"Schwarze-Zander","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"},{"name":"German Center for Infection Research, Thematical Translational Units HIV , Cologne\/Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Boesecke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn , Bonn , Germany"},{"name":"German Center for Infection Research, Thematical Translational Units HIV , Cologne\/Bonn , 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