{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:07:06Z","timestamp":1740128826876,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-68893 and CRN-83320"],"award-info":[{"award-number":["MOP-68893 and CRN-83320"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["AI073889"],"award-info":[{"award-number":["AI073889"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Merck & Co"},{"name":"R\u00e9seau Fonds de recherche du Qu\u00e9bec, R\u00e9seau sida et maladies infectieuses"},{"name":"Sigrid Juselius Foundation"},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Human leukocyte antigen (HLA) polymorphism influences innate and adaptive immune responses. Among heterosexual couples in the HPV Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) cohort study, we examined whether allele sharing in a couple predicted the partners\u2019 infections with the same human papillomavirus (HPV) type.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We tested genital samples from 271 couples for 36 HPV genotypes by polymerase chain reaction. We used direct DNA sequencing to type HLA-B07, -DRB1, -DQB1 and -G. Generalized estimating equations were used to examine the associations between the extent of allele sharing and HPV type concordance in which at least 1 of the partners was HPV positive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 106 different HLA alleles. The most common HLA alleles among couples were G*01:01:01 (95.6%), G*01:01:02 (60.1%), DQB1*03:01 (57.2%), and DRB1*07:01 (46.9%). Allele sharing was as follows: 19.6% shared none, 43.2% shared 1 only, 25.1% shared 2, and 12.5% shared 3\u20135. Irrespective of HLA class, grouped or in combination, the extent of allele sharing was not a significant predictor of type-specific HPV concordance in a couple (odds ratio,\u20051.1 [95% confidence interval, .5\u20132.1], for 3\u20135 vs none).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found no evidence that the extent of HLA allele concordance influences the likelihood of HPV transmission in newly formed heterosexual couples.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac115","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T11:11:52Z","timestamp":1648552312000},"page":"1175-1183","source":"Crossref","is-referenced-by-count":0,"title":["Role of Human Leukocyte Antigen Allele Sharing in Human Papillomavirus Infection Transmission Among Heterosexual Couples: Findings From the HITCH Cohort Study"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-363X","authenticated-orcid":false,"given":"Karolina","family":"Louvanto","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montreal, Quebec , Canada"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Technology, Tampere University , Tampere , Finland"},{"name":"Department of Obstetrics and Gynaecology, Tampere University Hospital , Tampere , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prativa","family":"Baral","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Burchell","sequence":"additional","affiliation":[{"name":"Ontario HIV Treatment Network , Toronto, Ontario , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnihotram","family":"Ramanakumar","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-0370","authenticated-orcid":false,"given":"Mariam","family":"El-Zein","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Paul","family":"Tellier","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, McGill University , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Coutl\u00e9e","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montreal, Quebec , Canada"},{"name":"Centre de recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al et D\u00e9partement de microbiologie, infectiologie et immunologie, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Roger","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al et D\u00e9partement de microbiologie, infectiologie et immunologie, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo L","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, McGill University , Montreal, Quebec , 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