{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T10:07:27Z","timestamp":1772273247798,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","funder":[{"name":"University of Pittsburgh Clinical and Translational Science Institute"},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K23HL139987"],"award-info":[{"award-number":["K23HL139987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01HL114453"],"award-info":[{"award-number":["P01HL114453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1OT2HL156812"],"award-info":[{"award-number":["1OT2HL156812"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"US Department of Veterans Affairs Biomedical Laboratory R&D Career Development Award","award":["IK2 BX004886"],"award-info":[{"award-number":["IK2 BX004886"]}]},{"name":"University of Pittsburgh Vascular Medicine Institute"},{"DOI":"10.13039\/100016251","name":"Hemophilia Center of Western Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016489","name":"Institute for Transfusion Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19 outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract (LRT) vRNA levels is unclear. We compared plasma and LRT vRNA levels in serially collected samples from mechanically ventilated patients with COVID-19. LRT and plasma vRNA levels were strongly correlated at first sampling (n = 33, r = 0.83, P &amp;lt; 10\u22129) and then declined in parallel in available serial samples except in nonsurvivors who exhibited delayed vRNA clearance in LRT samples. Plasma vRNA measurement may offer a practical surrogate of LRT vRNA burden in critically ill patients, especially early after ICU admission.<\/jats:p>","DOI":"10.1093\/infdis\/jiac157","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T15:25:06Z","timestamp":1650986706000},"page":"2089-2094","source":"Crossref","is-referenced-by-count":19,"title":["Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients With COVID-19"],"prefix":"10.1093","volume":"226","author":[{"given":"Jana L","family":"Jacobs","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Pittsburgh 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School of Medicine , Pittsburgh, Pennsylvania , USA"},{"name":"Center for Medicine and the Microbiome, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet S","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania , USA"},{"name":"Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania , USA"},{"name":"Center for Medicine and the Microbiome, Department of Medicine, 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