{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:28:04Z","timestamp":1792794484024,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100013373","name":"National Institute for Health Research (NIHR) Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Thames Valley and South Midlands Clinical Research Network"},{"name":"British Research Council"},{"name":"Respiratory Syncytial Virus Consortium in Europe"},{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["116019"],"award-info":[{"award-number":["116019"]}],"id":[{"id":"https:\/\/ror.org\/019af4n30","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Union Horizon 2020 Research and Innovation Program","id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants and young children worldwide. Here we evaluated host demographic and viral factors associated with RSV disease severity in 325 RSV-infected infants under 1 year of age from 3 European countries during 2017\u20132020. Younger infants had a higher clinical severity (ReSViNET) score and were more likely to require hospitalization, intensive care, respiratory support, and\/or mechanical ventilation than older infants (&amp;lt;3 months vs 3 to &amp;lt;6 months and 3 to &amp;lt;6 months vs \u22656 months). Older age (\u22656 months vs &amp;lt;3 months), higher viral load, and RSV-A were associated with a greater probability of fever. RSV-A and RSV-B caused similar disease severity and had similar viral dynamics. Infants with a more severe RSV infection, demonstrated by having a higher ReSViNET score, fever, and requiring hospitalization and intensive care, were more likely to have developed subsequent wheezing at 1 year of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trials Registration<\/jats:title>\n                    <jats:p>NCT03756766.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiac163","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T07:11:18Z","timestamp":1651216278000},"page":"S45-S54","source":"Crossref","is-referenced-by-count":34,"title":["Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection"],"prefix":"10.1093","volume":"226","author":[{"given":"Joseph P","family":"McGinley","sequence":"first","affiliation":[{"name":"Oxford Vaccine Group, Department of 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