{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:29:41Z","timestamp":1793388581068,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AI034533"],"award-info":[{"award-number":["P01AI034533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["804744"],"award-info":[{"award-number":["804744"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Dengue virus (DENV) often circulates endemically. In such settings with high levels of transmission, it remains unclear whether there are risk factors that alter individual infection risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We tested blood taken from individuals living in multigenerational households in Kamphaeng Phet province, Thailand for DENV antibodies (N = 2364, mean age 31 years). Seropositivity ranged from 45.4% among those 1\u20135 years old to 99.5% for those &amp;gt;30 years. Using spatially explicit catalytic models, we estimated that 11.8% of the susceptible population gets infected annually.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that 37.5% of the variance in seropositivity was explained by unmeasured household-level effects with only 4.2% explained by spatial differences between households. The serostatus of individuals from the same household remained significantly correlated even when separated by up to 15 years in age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings show that despite highly endemic transmission, persistent differences in infection risk exist across households, the reasons for which remain unclear.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac177","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T19:10:39Z","timestamp":1651518639000},"page":"1348-1356","source":"Crossref","is-referenced-by-count":19,"title":["Individual, Household, and Community Drivers of Dengue Virus Infection Risk in Kamphaeng Phet Province, Thailand"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-8755","authenticated-orcid":false,"given":"Gabriel","family":"Ribeiro dos Santos","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Cambridge , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darunee","family":"Buddhari","sequence":"additional","affiliation":[{"name":"Department of Virology, Armed Forces Research Institute of Medical Sciences , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sopon","family":"Iamsirithaworn","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Ministry of Public Health , Tiwanond, Nonthaburi , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Direk","family":"Khampaen","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Ministry of Public Health , Tiwanond, Nonthaburi , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alongkot","family":"Ponlawat","sequence":"additional","affiliation":[{"name":"Department of Entomology, Armed Forces Research Institute of Medical Sciences , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanyalak","family":"Fansiri","sequence":"additional","affiliation":[{"name":"Department of Entomology, Armed Forces Research Institute of Medical Sciences , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Virology, Armed Forces Research Institute of Medical Sciences , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Virology, Armed Forces Research Institute of Medical Sciences , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Medicine, SUNY Upstate Medical University, Syracuse , New York , USA"},{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse , New York , USA"},{"name":"Institute for Global Health and Translational Sciences, SUNY Upstate Medical University, Syracuse , New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Rodriguez Barraquer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anon","family":"Srikiatkhachorn","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island , Providence, Rhone Island , USA"},{"name":"Faculty of Medicine, King Mongkut\u2019s Institute of Technology Ladkrabang , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angkana T","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge , United Kingdom"},{"name":"Department of Virology, Armed Forces Research Institute of Medical Sciences , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A T","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Florida , Gainesville , USA"},{"name":"Emerging Pathogens Institute, University of Florida , Gainesville , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Endy","sequence":"additional","affiliation":[{"name":"Department of Medicine, SUNY Upstate Medical University, Syracuse , New York , USA"},{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse , New York , USA"},{"name":"Institute for Global Health and Translational Sciences, SUNY Upstate Medical University, Syracuse , New York , USA"},{"name":"Coalition for Epidemic Preparedness Innovations (CEPI) , Washington, District of Columbia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L","family":"Rothman","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island , Providence, Rhone Island , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-4254","authenticated-orcid":false,"given":"Henrik","family":"Salje","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge , United Kingdom"},{"name":"Department of Biology, University of Florida , Gainesville , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-2351","authenticated-orcid":false,"given":"Kathryn B","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Virology, Armed Forces Research Institute of Medical Sciences , Bangkok , Thailand"},{"name":"Department of Medicine, SUNY Upstate Medical University, Syracuse , New York , USA"},{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse , New York , USA"},{"name":"Institute for Global Health and Translational Sciences, SUNY Upstate Medical University, Syracuse , New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"2022101708572038100_jiac177-B1","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue","volume":"370","author":"Halstead","journal-title":"Lancet"},{"key":"2022101708572038100_jiac177-B2","doi-asserted-by":"crossref","first-page":"e1000139","DOI":"10.1371\/journal.pmed.1000139","article-title":"The impact of the demographic transition on dengue in Thailand: insights from a statistical analysis and mathematical modeling","volume":"6","author":"Cummings","year":"2009","journal-title":"PLoS Med"},{"key":"2022101708572038100_jiac177-B3","doi-asserted-by":"crossref","first-page":"e757","DOI":"10.1371\/journal.pntd.0000757","article-title":"Emergence of the Asian 1 genotype of dengue virus serotype 2 in Viet Nam: in vivo fitness advantage and lineage replacement in South-East Asia","volume":"4","author":"Vu","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41586-018-0157-4","article-title":"Reconstruction of antibody dynamics and infection histories to evaluate dengue risk","volume":"557","author":"Salje","year":"2018","journal-title":"Nature"},{"key":"2022101708572038100_jiac177-B5","doi-asserted-by":"crossref","first-page":"13069","DOI":"10.1073\/pnas.1501375112","article-title":"Region-wide synchrony and traveling waves of dengue across eight countries in Southeast Asia","volume":"112","author":"van Panhuis","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022101708572038100_jiac177-B6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4269\/ajtmh.2005.72.209","article-title":"Dispersal of the dengue vector Aedes aegypti within and between rural communities","volume":"72","author":"Harrington","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"2022101708572038100_jiac177-B7","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/s41467-021-21888-9","article-title":"Reconstructing unseen transmission events to infer dengue dynamics from viral sequences","volume":"12","author":"Salje","year":"2021","journal-title":"Nat Commun"},{"key":"2022101708572038100_jiac177-B8","doi-asserted-by":"crossref","first-page":"e3138","DOI":"10.1371\/journal.pntd.0003138","article-title":"The spatial dynamics of dengue virus in Kamphaeng Phet, Thailand","volume":"8","author":"Bhoomiboonchoo","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fpubh.2020.00002","article-title":"Key findings and comparisons from analogous case-cluster studies for dengue virus infection conducted in Machala, Ecuador, and Kamphaeng Phet, Thailand","volume":"8","author":"Anderson","year":"2020","journal-title":"Front Public Health"},{"key":"2022101708572038100_jiac177-B10","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1126\/science.aaj9384","article-title":"Dengue diversity across spatial and temporal scales: Local structure and the effect of host population size","volume":"355","author":"Salje","year":"2017","journal-title":"Science"},{"key":"2022101708572038100_jiac177-B11","doi-asserted-by":"crossref","first-page":"e1002218","DOI":"10.1371\/journal.pmed.1002218","article-title":"Evaluating hospital-based surveillance for outbreak detection in Bangladesh: analysis of healthcare utilization data","volume":"14","author":"Nikolay","year":"2017","journal-title":"PLoS Med"},{"key":"2022101708572038100_jiac177-B12","doi-asserted-by":"crossref","first-page":"e2848","DOI":"10.1371\/journal.pntd.0002848","article-title":"Assessing the relationship between vector indices and dengue transmission: a systematic review of the evidence","volume":"8","author":"Bowman","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B13","doi-asserted-by":"crossref","first-page":"e0008703","DOI":"10.1371\/journal.pntd.0008703","article-title":"Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand","volume":"14","author":"Fustec","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B14","doi-asserted-by":"crossref","first-page":"e0009475","DOI":"10.1371\/journal.pntd.0009475","article-title":"Short report: Adult Aedes abundance and risk of dengue transmission","volume":"15","author":"Ong","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.actatropica.2018.02.018","article-title":"Using adult Aedes aegypti females to predict areas at risk for dengue transmission: a spatial case-control study","volume":"182","author":"Parra","year":"2018","journal-title":"Acta Trop"},{"key":"2022101708572038100_jiac177-B16","doi-asserted-by":"crossref","first-page":"e42869","DOI":"10.7554\/eLife.42869","article-title":"Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates","volume":"8","author":"Salje","year":"2019","journal-title":"Elife"},{"key":"2022101708572038100_jiac177-B17","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3390\/v13071299","article-title":"Spatial distribution and burden of emerging arboviruses in French Guiana","volume":"13","author":"Bailly","year":"2021","journal-title":"Viruses"},{"key":"2022101708572038100_jiac177-B18","doi-asserted-by":"crossref","first-page":"e0003719","DOI":"10.1371\/journal.pntd.0003719","article-title":"Estimating dengue transmission intensity from sero-prevalence surveys in multiple countries","volume":"9","author":"Imai","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B19","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/infdis\/jiv470","article-title":"Reconstruction of 60 years of chikungunya epidemiology in the Philippines demonstrates episodic and focal transmission","volume":"213","author":"Salje","year":"2016","journal-title":"J Infect Dis"},{"key":"2022101708572038100_jiac177-B20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/aje\/kwt256","article-title":"Revisiting Rayong: shifting seroprofiles of dengue in Thailand and their implications for transmission and control","volume":"179","author":"Rodr\u00edguez-Barraquer","year":"2014","journal-title":"Am J Epidemiol"},{"key":"2022101708572038100_jiac177-B21","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/aje\/kwaa008","article-title":"An innovative, prospective, hybrid cohort-cluster study design to characterize dengue virus transmission in multigenerational households in Kamphaeng Phet, Thailand","volume":"189","author":"Anderson","year":"2020","journal-title":"Am J Epidemiol"},{"key":"2022101708572038100_jiac177-B22","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3390\/pathogens10101234","article-title":"Entomological risk assessment for dengue virus transmission during 2016\u20132020 in Kamphaeng Phet, Thailand","volume":"10","author":"Fansiri","year":"2021","journal-title":"Pathogens"},{"key":"2022101708572038100_jiac177-B23","first-page":"23","article-title":"Investigations on the presence of hemagglutination-inhibiting antibodies to dengue virus in apparently healthy subjects of several counties in Romania","volume":"26","author":"Dr\u0103g\u0103nescu","year":"1975","journal-title":"Virologie"},{"key":"2022101708572038100_jiac177-B24","volume-title":"geoS: a geostatistical library for S-PLUS","author":"Ribeiro","year":"1999"},{"key":"2022101708572038100_jiac177-B25","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-97487-3","volume-title":"Epidemics: models and data using R","author":"Bj\u00f8rnstad","year":"2018"},{"key":"2022101708572038100_jiac177-B26","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1098\/rstb.1999.0428","article-title":"Transmission dynamics and epidemiology of dengue: insights from age-stratified sero-prevalence surveys","volume":"354","author":"Ferguson","year":"1999","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2022101708572038100_jiac177-B27","doi-asserted-by":"crossref","first-page":"e0005188","DOI":"10.1371\/journal.pntd.0005188","article-title":"Synchrony of dengue incidence in Ho Chi Minh City and Bangkok","volume":"10","author":"Hoang Quoc","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B28","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1186\/s12889-016-3496-9","article-title":"Rural-urban comparisons of dengue seroprevalence in Malaysia","volume":"16","author":"Chew","year":"2016","journal-title":"BMC Public Health"},{"key":"2022101708572038100_jiac177-B29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.4269\/ajtmh.1985.34.625","article-title":"Dengue transmission in two Puerto Rican communities in 1982","volume":"34","author":"Waterman","year":"1985","journal-title":"Am J Trop Med Hyg"},{"key":"2022101708572038100_jiac177-B30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/oxfordjournals.aje.a116487","article-title":"The predisposing and protective factors against dengue virus transmission by mosquito vector","volume":"136","author":"Ko","year":"1992","journal-title":"Am J Epidemiol"},{"key":"2022101708572038100_jiac177-B31","doi-asserted-by":"crossref","first-page":"e0004551","DOI":"10.1371\/journal.pntd.0004551","article-title":"Is dengue vector control deficient in effectiveness or evidence?: systematic review and meta-analysis","volume":"10","author":"Bowman","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B32","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/oxfordjournals.aje.a009589","article-title":"Determinants of dengue 2 infection among residents of Charters Towers, Queensland, Australia","volume":"148","author":"McBride","year":"1998","journal-title":"Am J Epidemiol"},{"key":"2022101708572038100_jiac177-B33","doi-asserted-by":"crossref","first-page":"e0005429","DOI":"10.1371\/journal.pntd.0005429","article-title":"The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection","volume":"11","author":"Cromwell","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"2022101708572038100_jiac177-B34","doi-asserted-by":"crossref","first-page":"e1730","DOI":"10.1371\/journal.pntd.0001730","article-title":"Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages","volume":"6","author":"Yoon","year":"2012","journal-title":"PLoS Negl Trop Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiac177\/43922465\/jiac177.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/226\/8\/1348\/46542809\/jiac177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/226\/8\/1348\/46542809\/jiac177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T08:58:46Z","timestamp":1665997126000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/226\/8\/1348\/6580084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":34,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,5,4]]},"published-print":{"date-parts":[[2022,10,17]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiac177","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10,15]]},"published":{"date-parts":[[2022,5,4]]}}}