{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:39:21Z","timestamp":1790627961638,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021716","name":"Universit\u00e9 de Paris","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100021716","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Staphylococcus aureus dominates the lung microbiota of children with cystic fibrosis (CF) and persistent clones are able to establish chronic infection for years, having a direct deleterious impact on lung function. However, in this context, the exact contribution of S. aureus to the decline in respiratory function in children with CF is not elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To investigate the contribution of persistent S. aureus clones in CF disease, we undertook the analysis of sequential isogenic isolates recovered from 15 young CF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using an air-liquid infection model, we observed a strong correlation between S. aureus adaption in the lung (late isolates), low toxicity, and proinflammatory cytokine secretion. Conversely, early isolates appeared to be highly cytotoxic but did not promote cytokine secretion. We found that cytokine secretion was dependent on staphylococcal protein A (Spa), which was selectively expressed in late compared to early isolates as a consequence of dysfunctional agr quorum-sensing system. Finally, we demonstrated the involvement of TNF-\u03b1 receptor 1 signaling in the inflammatory response of airway epithelial cells to these lung-adapted S. aureus isolates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest an unexpected direct role of bacterial lung adaptation in the progression of chronic lung disease by promoting a proinflammatory response through acquired agr dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiac191","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T15:59:19Z","timestamp":1651766359000},"page":"1276-1285","source":"Crossref","is-referenced-by-count":16,"title":["Lung-Adapted\n                    <i>Staphylococcus aureus<\/i>\n                    Isolates With Dysfunctional Agr System Trigger a Proinflammatory Response"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-7070","authenticated-orcid":false,"given":"Elodie","family":"Ramond","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Pathogenesis of Systemic Infections, Institut Necker-Enfants Malades, Inserm U1151-CNRS UMR 8253 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Lepissier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Epithelial Channelopathies, Cystic Fibrosis, and Other Diseases, Institut Necker-Enfants Malades, Inserm U1151-CNRS UMR 8253, , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongqi","family":"Ding","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Pathogenesis of Systemic Infections, Institut Necker-Enfants 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Nemazanyy","sequence":"additional","affiliation":[{"name":"Platform for Metabolic Analyses, Structure F\u00e9d\u00e9rative de Recherche Necker, Inserm US24-CNRS UMS 3633 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nassif","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Pathogenesis of Systemic Infections, Institut Necker-Enfants Malades, Inserm U1151-CNRS UMR 8253 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Ferroni","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Necker-Enfants Malades Hospital, AP-HP Centre Universit\u00e9 de Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Sermet-Gaudelus","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Epithelial Channelopathies, Cystic Fibrosis, and Other Diseases, Institut Necker-Enfants Malades, Inserm U1151-CNRS UMR 8253, , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Charbit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Pathogenesis of Systemic Infections, Institut Necker-Enfants Malades, Inserm U1151-CNRS UMR 8253 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-9685","authenticated-orcid":false,"given":"Mathieu","family":"Coureuil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Pathogenesis of Systemic Infections, 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